Anti-ASH2L monoclonal antibody

Pre-made anti-ASH2L monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to ASH2L/ASH2L products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP2362-Ab-1/ GM-Tg-hg-IP2362-Ab-2Anti-Human ASH2L monoclonal antibodyHuman
GM-Tg-rg-IP2362-Ab-1/ GM-Tg-rg-IP2362-Ab-2Anti-Rat ASH2L monoclonal antibodyRat
GM-Tg-mg-IP2362-Ab-1/ GM-Tg-mg-IP2362-Ab-2Anti-Mouse ASH2L monoclonal antibodyMouse
GM-Tg-cynog-IP2362-Ab-1/ GM-Tg-cynog-IP2362-Ab-2Anti-Cynomolgus/ Rhesus macaque ASH2L monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP2362-Ab-1/ GM-Tg-felg-IP2362-Ab-2Anti-Feline ASH2L monoclonal antibodyFeline
GM-Tg-cang-IP2362-Ab-1/ GM-Tg-cang-IP2362-Ab-2Anti-Canine ASH2L monoclonal antibodyCanine
GM-Tg-bovg-IP2362-Ab-1/ GM-Tg-bovg-IP2362-Ab-2Anti-Bovine ASH2L monoclonal antibodyBovine
GM-Tg-equg-IP2362-Ab-1/ GM-Tg-equg-IP2362-Ab-2Anti-Equine ASH2L monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP2362-Ab-1/ GM-Tg-hg-IP2362-Ab-2; GM-Tg-rg-IP2362-Ab-1/ GM-Tg-rg-IP2362-Ab-2;
GM-Tg-mg-IP2362-Ab-1/ GM-Tg-mg-IP2362-Ab-2; GM-Tg-cynog-IP2362-Ab-1/ GM-Tg-cynog-IP2362-Ab-2;
GM-Tg-felg-IP2362-Ab-1/ GM-Tg-felg-IP2362-Ab-2; GM-Tg-cang-IP2362-Ab-1/ GM-Tg-cang-IP2362-Ab-2;
GM-Tg-bovg-IP2362-Ab-1/ GM-Tg-bovg-IP2362-Ab-2; GM-Tg-equg-IP2362-Ab-1/ GM-Tg-equg-IP2362-Ab-2
Products NameAnti-ASH2L monoclonal antibody
Formatmab
Target NameASH2L
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-ASH2L monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP2362-Ag-1Recombinant multi-species ASH2L/ ASH21/ ASH2L2 protein


    Target information

    Target IDGM-IP2362
    Target NameASH2L
    Gene ID9070,23808,290829,699382,475589,101088324,100138350,100059465
    Gene Symbol and SynonymsASH2,ash2-like,ASH2L,ASH2L1,ASH2L2,Bre2
    Uniprot AccessionQ9UBL3
    Uniprot Entry NameASH2L_HUMAN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000129691
    Target ClassificationN/A

    The target: ASH2L, gene name: ASH2L, also named as ASH21, ASH2L2, Bre2, ASH2L. Enables beta-catenin binding activity and transcription cis-regulatory region binding activity. Contributes to histone methyltransferase activity (H3-K4 specific). Involved in histone H3-K4 methylation; positive regulation of cell population proliferation; and response to estrogen. Acts upstream of or within cellular response to DNA damage stimulus. Located in nucleus. Part of MLL3/4 complex and Set1C/COMPASS complex. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.