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Anti-BCAR3 monoclonal antibody
Pre-made anti-BCAR3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to BCAR3/BCAR3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2372-Ab-1/ GM-Tg-hg-IP2372-Ab-2 | Anti-Human BCAR3 monoclonal antibody | Human |
| GM-Tg-rg-IP2372-Ab-1/ GM-Tg-rg-IP2372-Ab-2 | Anti-Rat BCAR3 monoclonal antibody | Rat |
| GM-Tg-mg-IP2372-Ab-1/ GM-Tg-mg-IP2372-Ab-2 | Anti-Mouse BCAR3 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2372-Ab-1/ GM-Tg-cynog-IP2372-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BCAR3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2372-Ab-1/ GM-Tg-felg-IP2372-Ab-2 | Anti-Feline BCAR3 monoclonal antibody | Feline |
| GM-Tg-cang-IP2372-Ab-1/ GM-Tg-cang-IP2372-Ab-2 | Anti-Canine BCAR3 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2372-Ab-1/ GM-Tg-bovg-IP2372-Ab-2 | Anti-Bovine BCAR3 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2372-Ab-1/ GM-Tg-equg-IP2372-Ab-2 | Anti-Equine BCAR3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2372-Ab-1/ GM-Tg-hg-IP2372-Ab-2; GM-Tg-rg-IP2372-Ab-1/ GM-Tg-rg-IP2372-Ab-2; GM-Tg-mg-IP2372-Ab-1/ GM-Tg-mg-IP2372-Ab-2; GM-Tg-cynog-IP2372-Ab-1/ GM-Tg-cynog-IP2372-Ab-2; GM-Tg-felg-IP2372-Ab-1/ GM-Tg-felg-IP2372-Ab-2; GM-Tg-cang-IP2372-Ab-1/ GM-Tg-cang-IP2372-Ab-2; GM-Tg-bovg-IP2372-Ab-1/ GM-Tg-bovg-IP2372-Ab-2; GM-Tg-equg-IP2372-Ab-1/ GM-Tg-equg-IP2372-Ab-2 |
| Products Name | Anti-BCAR3 monoclonal antibody |
| Format | mab |
| Target Name | BCAR3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-BCAR3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2372-Ag-1 | Recombinant multi-species BCAR3/ AND-34/ NSP2 protein |
| ORF Viral Vector | vGMLP002042 | human BCAR3 Lentivirus particle |
| ORF Viral Vector | pGMLP002042 | human BCAR3 Lentivirus plasmid |
Target information
| Target ID | GM-IP2372 |
| Target Name | BCAR3 |
| Gene ID | 8412,29815,310838,713636,479941,101099315,506231,100059015 |
| Gene Symbol and Synonyms | AND-34,BCAR3,MIG7,NSP2,SH2D3B |
| Uniprot Accession | O75815,D3ZAZ5,Q58DL5 |
| Uniprot Entry Name | BCAR3_HUMAN,BCAR3_RAT,BCAR3_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000137936 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: BCAR3, gene name: BCAR3, also named as AND-34, NSP2, SH2D3B. Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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