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Anti-BCL2L12 monoclonal antibody
Pre-made anti-BCL2L12 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to BCL2L12/BCL2L12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2373-Ab-1/ GM-Tg-hg-IP2373-Ab-2 | Anti-Human BCL2L12 monoclonal antibody | Human |
| GM-Tg-rg-IP2373-Ab-1/ GM-Tg-rg-IP2373-Ab-2 | Anti-Rat BCL2L12 monoclonal antibody | Rat |
| GM-Tg-mg-IP2373-Ab-1/ GM-Tg-mg-IP2373-Ab-2 | Anti-Mouse BCL2L12 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2373-Ab-1/ GM-Tg-cynog-IP2373-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BCL2L12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2373-Ab-1/ GM-Tg-felg-IP2373-Ab-2 | Anti-Feline BCL2L12 monoclonal antibody | Feline |
| GM-Tg-cang-IP2373-Ab-1/ GM-Tg-cang-IP2373-Ab-2 | Anti-Canine BCL2L12 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2373-Ab-1/ GM-Tg-bovg-IP2373-Ab-2 | Anti-Bovine BCL2L12 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2373-Ab-1/ GM-Tg-equg-IP2373-Ab-2 | Anti-Equine BCL2L12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2373-Ab-1/ GM-Tg-hg-IP2373-Ab-2; GM-Tg-rg-IP2373-Ab-1/ GM-Tg-rg-IP2373-Ab-2; GM-Tg-mg-IP2373-Ab-1/ GM-Tg-mg-IP2373-Ab-2; GM-Tg-cynog-IP2373-Ab-1/ GM-Tg-cynog-IP2373-Ab-2; GM-Tg-felg-IP2373-Ab-1/ GM-Tg-felg-IP2373-Ab-2; GM-Tg-cang-IP2373-Ab-1/ GM-Tg-cang-IP2373-Ab-2; GM-Tg-bovg-IP2373-Ab-1/ GM-Tg-bovg-IP2373-Ab-2; GM-Tg-equg-IP2373-Ab-1/ GM-Tg-equg-IP2373-Ab-2 |
| Products Name | Anti-BCL2L12 monoclonal antibody |
| Format | mab |
| Target Name | BCL2L12 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-BCL2L12 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2373-Ag-1 | Recombinant multi-species B2L12/ BCL2L12 protein |
| ORF Viral Vector | pGMLP000231 | human BCL2L12 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000231 | human BCL2L12 Lentivirus particle |
| ORF Viral Vector | pGMLPm000537 | mouse Bcl2l12 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000537 | mouse Bcl2l12 Lentivirus particle |
Target information
| Target ID | GM-IP2373 |
| Target Name | BCL2L12 |
| Gene ID | 83596,75736,361567,718981,100688537,101080498,533338,100055909 |
| Gene Symbol and Synonyms | 2810475P17Rik,5430429M05Rik,Bcl-L12,Bcl2-L12,BCL2L12 |
| Uniprot Accession | Q9HB09 |
| Uniprot Entry Name | B2L12_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000126453 |
| Target Classification | N/A |
The target: BCL2L12, gene name: BCL2L12, also named as . This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
