Anti-BCL2L12 monoclonal antibody

Pre-made anti-BCL2L12 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to BCL2L12/BCL2L12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP2373-Ab-1/ GM-Tg-hg-IP2373-Ab-2Anti-Human BCL2L12 monoclonal antibodyHuman
GM-Tg-rg-IP2373-Ab-1/ GM-Tg-rg-IP2373-Ab-2Anti-Rat BCL2L12 monoclonal antibodyRat
GM-Tg-mg-IP2373-Ab-1/ GM-Tg-mg-IP2373-Ab-2Anti-Mouse BCL2L12 monoclonal antibodyMouse
GM-Tg-cynog-IP2373-Ab-1/ GM-Tg-cynog-IP2373-Ab-2Anti-Cynomolgus/ Rhesus macaque BCL2L12 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP2373-Ab-1/ GM-Tg-felg-IP2373-Ab-2Anti-Feline BCL2L12 monoclonal antibodyFeline
GM-Tg-cang-IP2373-Ab-1/ GM-Tg-cang-IP2373-Ab-2Anti-Canine BCL2L12 monoclonal antibodyCanine
GM-Tg-bovg-IP2373-Ab-1/ GM-Tg-bovg-IP2373-Ab-2Anti-Bovine BCL2L12 monoclonal antibodyBovine
GM-Tg-equg-IP2373-Ab-1/ GM-Tg-equg-IP2373-Ab-2Anti-Equine BCL2L12 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP2373-Ab-1/ GM-Tg-hg-IP2373-Ab-2; GM-Tg-rg-IP2373-Ab-1/ GM-Tg-rg-IP2373-Ab-2;
GM-Tg-mg-IP2373-Ab-1/ GM-Tg-mg-IP2373-Ab-2; GM-Tg-cynog-IP2373-Ab-1/ GM-Tg-cynog-IP2373-Ab-2;
GM-Tg-felg-IP2373-Ab-1/ GM-Tg-felg-IP2373-Ab-2; GM-Tg-cang-IP2373-Ab-1/ GM-Tg-cang-IP2373-Ab-2;
GM-Tg-bovg-IP2373-Ab-1/ GM-Tg-bovg-IP2373-Ab-2; GM-Tg-equg-IP2373-Ab-1/ GM-Tg-equg-IP2373-Ab-2
Products NameAnti-BCL2L12 monoclonal antibody
Formatmab
Target NameBCL2L12
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-BCL2L12 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP2373-Ag-1Recombinant multi-species B2L12/ BCL2L12 protein
    ORF Viral VectorpGMLP000231human BCL2L12 Lentivirus plasmid
    ORF Viral VectorvGMLP000231human BCL2L12 Lentivirus particle
    ORF Viral VectorpGMLPm000537mouse Bcl2l12 Lentivirus plasmid
    ORF Viral VectorvGMLPm000537mouse Bcl2l12 Lentivirus particle


    Target information

    Target IDGM-IP2373
    Target NameBCL2L12
    Gene ID83596,75736,361567,718981,100688537,101080498,533338,100055909
    Gene Symbol and Synonyms2810475P17Rik,5430429M05Rik,Bcl-L12,Bcl2-L12,BCL2L12
    Uniprot AccessionQ9HB09
    Uniprot Entry NameB2L12_HUMAN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000126453
    Target ClassificationN/A

    The target: BCL2L12, gene name: BCL2L12, also named as . This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.