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Anti-EIF5B monoclonal antibody
Pre-made anti-EIF5B monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to EIF5B/EIF5B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2471-Ab-1/ GM-Tg-hg-IP2471-Ab-2 | Anti-Human EIF5B monoclonal antibody | Human |
| GM-Tg-rg-IP2471-Ab-1/ GM-Tg-rg-IP2471-Ab-2 | Anti-Rat EIF5B monoclonal antibody | Rat |
| GM-Tg-mg-IP2471-Ab-1/ GM-Tg-mg-IP2471-Ab-2 | Anti-Mouse EIF5B monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2471-Ab-1/ GM-Tg-cynog-IP2471-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EIF5B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2471-Ab-1/ GM-Tg-felg-IP2471-Ab-2 | Anti-Feline EIF5B monoclonal antibody | Feline |
| GM-Tg-cang-IP2471-Ab-1/ GM-Tg-cang-IP2471-Ab-2 | Anti-Canine EIF5B monoclonal antibody | Canine |
| GM-Tg-bovg-IP2471-Ab-1/ GM-Tg-bovg-IP2471-Ab-2 | Anti-Bovine EIF5B monoclonal antibody | Bovine |
| GM-Tg-equg-IP2471-Ab-1/ GM-Tg-equg-IP2471-Ab-2 | Anti-Equine EIF5B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2471-Ab-1/ GM-Tg-hg-IP2471-Ab-2; GM-Tg-rg-IP2471-Ab-1/ GM-Tg-rg-IP2471-Ab-2; GM-Tg-mg-IP2471-Ab-1/ GM-Tg-mg-IP2471-Ab-2; GM-Tg-cynog-IP2471-Ab-1/ GM-Tg-cynog-IP2471-Ab-2; GM-Tg-felg-IP2471-Ab-1/ GM-Tg-felg-IP2471-Ab-2; GM-Tg-cang-IP2471-Ab-1/ GM-Tg-cang-IP2471-Ab-2; GM-Tg-bovg-IP2471-Ab-1/ GM-Tg-bovg-IP2471-Ab-2; GM-Tg-equg-IP2471-Ab-1/ GM-Tg-equg-IP2471-Ab-2 |
| Products Name | Anti-EIF5B monoclonal antibody |
| Format | mab |
| Target Name | EIF5B |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-EIF5B monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2471-Ag-1 | Recombinant multi-species IF2P/ EIF5B/ IF2 protein |
Target information
| Target ID | GM-IP2471 |
| Target Name | EIF5B |
| Gene ID | 9669,226982,308306,714129,474556,101095815,532850,100050422 |
| Gene Symbol and Synonyms | A030003E17Rik,EIF5B,IF2 |
| Uniprot Accession | O60841,B2GUV7 |
| Uniprot Entry Name | IF2P_HUMAN,IF2P_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000158417 |
| Target Classification | N/A |
The target: EIF5B, gene name: EIF5B, also named as IF2. Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
