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Anti-FOXA2 monoclonal antibody
Pre-made anti-FOXA2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to FOXA2/FOXA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2505-Ab-1/ GM-Tg-hg-IP2505-Ab-2 | Anti-Human FOXA2 monoclonal antibody | Human |
| GM-Tg-rg-IP2505-Ab-1/ GM-Tg-rg-IP2505-Ab-2 | Anti-Rat FOXA2 monoclonal antibody | Rat |
| GM-Tg-mg-IP2505-Ab-1/ GM-Tg-mg-IP2505-Ab-2 | Anti-Mouse FOXA2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2505-Ab-1/ GM-Tg-cynog-IP2505-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FOXA2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2505-Ab-1/ GM-Tg-felg-IP2505-Ab-2 | Anti-Feline FOXA2 monoclonal antibody | Feline |
| GM-Tg-cang-IP2505-Ab-1/ GM-Tg-cang-IP2505-Ab-2 | Anti-Canine FOXA2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2505-Ab-1/ GM-Tg-bovg-IP2505-Ab-2 | Anti-Bovine FOXA2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2505-Ab-1/ GM-Tg-equg-IP2505-Ab-2 | Anti-Equine FOXA2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2505-Ab-1/ GM-Tg-hg-IP2505-Ab-2; GM-Tg-rg-IP2505-Ab-1/ GM-Tg-rg-IP2505-Ab-2; GM-Tg-mg-IP2505-Ab-1/ GM-Tg-mg-IP2505-Ab-2; GM-Tg-cynog-IP2505-Ab-1/ GM-Tg-cynog-IP2505-Ab-2; GM-Tg-felg-IP2505-Ab-1/ GM-Tg-felg-IP2505-Ab-2; GM-Tg-cang-IP2505-Ab-1/ GM-Tg-cang-IP2505-Ab-2; GM-Tg-bovg-IP2505-Ab-1/ GM-Tg-bovg-IP2505-Ab-2; GM-Tg-equg-IP2505-Ab-1/ GM-Tg-equg-IP2505-Ab-2 |
| Products Name | Anti-FOXA2 monoclonal antibody |
| Format | mab |
| Target Name | FOXA2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-FOXA2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2505-Ag-1 | Recombinant multi-species FOXA2/ HNF3B/ TCF3B protein |
| ORF Viral Vector | pGMLPm004974 | mouse Foxa2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004974 | mouse Foxa2 Lentivirus particle |
Target information
| Target ID | GM-IP2505 |
| Target Name | FOXA2 |
| Gene ID | 3170,15376,25099,701771,485742,101085112,101906272,100147413 |
| Gene Symbol and Synonyms | FOXA2,HNF-3-beta,Hnf-3b,HNF3-beta,HNF3B,HNF3beta,Tcf-3b,TCF3B |
| Uniprot Accession | Q9Y261,P32182 |
| Uniprot Entry Name | FOXA2_HUMAN,FOXA2_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000125798 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: FOXA2, gene name: FOXA2, also named as HNF3B, TCF3B. This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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