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Anti-GLIS2 monoclonal antibody
Pre-made anti-GLIS2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to GLIS2/GLIS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2526-Ab-1/ GM-Tg-hg-IP2526-Ab-2 | Anti-Human GLIS2 monoclonal antibody | Human |
| GM-Tg-rg-IP2526-Ab-1/ GM-Tg-rg-IP2526-Ab-2 | Anti-Rat GLIS2 monoclonal antibody | Rat |
| GM-Tg-mg-IP2526-Ab-1/ GM-Tg-mg-IP2526-Ab-2 | Anti-Mouse GLIS2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2526-Ab-1/ GM-Tg-cynog-IP2526-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GLIS2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2526-Ab-1/ GM-Tg-felg-IP2526-Ab-2 | Anti-Feline GLIS2 monoclonal antibody | Feline |
| GM-Tg-cang-IP2526-Ab-1/ GM-Tg-cang-IP2526-Ab-2 | Anti-Canine GLIS2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2526-Ab-1/ GM-Tg-bovg-IP2526-Ab-2 | Anti-Bovine GLIS2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2526-Ab-1/ GM-Tg-equg-IP2526-Ab-2 | Anti-Equine GLIS2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2526-Ab-1/ GM-Tg-hg-IP2526-Ab-2; GM-Tg-rg-IP2526-Ab-1/ GM-Tg-rg-IP2526-Ab-2; GM-Tg-mg-IP2526-Ab-1/ GM-Tg-mg-IP2526-Ab-2; GM-Tg-cynog-IP2526-Ab-1/ GM-Tg-cynog-IP2526-Ab-2; GM-Tg-felg-IP2526-Ab-1/ GM-Tg-felg-IP2526-Ab-2; GM-Tg-cang-IP2526-Ab-1/ GM-Tg-cang-IP2526-Ab-2; GM-Tg-bovg-IP2526-Ab-1/ GM-Tg-bovg-IP2526-Ab-2; GM-Tg-equg-IP2526-Ab-1/ GM-Tg-equg-IP2526-Ab-2 |
| Products Name | Anti-GLIS2 monoclonal antibody |
| Format | mab |
| Target Name | GLIS2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-GLIS2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2526-Ag-1 | Recombinant multi-species GLIS2/ NKL/ NPHP7 protein |
| ORF Viral Vector | pGMLPm004412 | mouse Glis2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004412 | mouse Glis2 Lentivirus particle |
Target information
| Target ID | GM-IP2526 |
| Target Name | GLIS2 |
| Gene ID | 84662,83396,302946,708454,490028,101095217,527935,100066071 |
| Gene Symbol and Synonyms | Gli5,GLIS2,Klf16,NKL,NPHP7 |
| Uniprot Accession | Q9BZE0 |
| Uniprot Entry Name | GLIS2_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000126603 |
| Target Classification | N/A |
The target: GLIS2, gene name: GLIS2, also named as NKL, NPHP7. This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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