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Anti-KIAA0556 monoclonal antibody
Pre-made anti-KIAA0556 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to KIAA0556/KIAA0556 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2556-Ab-1/ GM-Tg-hg-IP2556-Ab-2 | Anti-Human KIAA0556 monoclonal antibody | Human |
| GM-Tg-rg-IP2556-Ab-1/ GM-Tg-rg-IP2556-Ab-2 | Anti-Rat KIAA0556 monoclonal antibody | Rat |
| GM-Tg-mg-IP2556-Ab-1/ GM-Tg-mg-IP2556-Ab-2 | Anti-Mouse KIAA0556 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2556-Ab-1/ GM-Tg-cynog-IP2556-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KIAA0556 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2556-Ab-1/ GM-Tg-felg-IP2556-Ab-2 | Anti-Feline KIAA0556 monoclonal antibody | Feline |
| GM-Tg-cang-IP2556-Ab-1/ GM-Tg-cang-IP2556-Ab-2 | Anti-Canine KIAA0556 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2556-Ab-1/ GM-Tg-bovg-IP2556-Ab-2 | Anti-Bovine KIAA0556 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2556-Ab-1/ GM-Tg-equg-IP2556-Ab-2 | Anti-Equine KIAA0556 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2556-Ab-1/ GM-Tg-hg-IP2556-Ab-2; GM-Tg-rg-IP2556-Ab-1/ GM-Tg-rg-IP2556-Ab-2; GM-Tg-mg-IP2556-Ab-1/ GM-Tg-mg-IP2556-Ab-2; GM-Tg-cynog-IP2556-Ab-1/ GM-Tg-cynog-IP2556-Ab-2; GM-Tg-felg-IP2556-Ab-1/ GM-Tg-felg-IP2556-Ab-2; GM-Tg-cang-IP2556-Ab-1/ GM-Tg-cang-IP2556-Ab-2; GM-Tg-bovg-IP2556-Ab-1/ GM-Tg-bovg-IP2556-Ab-2; GM-Tg-equg-IP2556-Ab-1/ GM-Tg-equg-IP2556-Ab-2 |
| Products Name | Anti-KIAA0556 monoclonal antibody |
| Format | mab |
| Target Name | KIAA0556 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-KIAA0556 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2556-Ag-1 | Recombinant multi-species KATIP/ KIAA0556/ JBTS26 protein |
Target information
| Target ID | GM-IP2556 |
| Target Name | KIAA0556 |
| Gene ID | 23247,233865,361646,706125,479799,101095302,520970,100066772 |
| Gene Symbol and Synonyms | D430042O09Rik,JBTS26,KATNIP,KIAA0556,RGD1307324 |
| Uniprot Accession | O60303 |
| Uniprot Entry Name | KATIP_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000047578 |
| Target Classification | N/A |
The target: KIAA0556, gene name: KIAA0556, also named as JBTS26. This gene encodes a novel, evolutionarily conserved, ciliary protein. In human hTERT-RPE1 cells, the protein is found at the base of cilia, decorating the ciliary axoneme, and enriched at the ciliary tip. The protein binds to microtubules in vitro and regulates their stability when it is overexpressed. A null mutation in this gene has been associated with Joubert syndrome, a recessive disorder that is characterized by a distinctive mid-hindbrain and cerebellar malformation and is also often associated with wider ciliopathy symptoms. Consistently, in a serum-starvation ciliogenesis assay, human fibroblast cells derived from patients with the mutation display a reduced number of ciliated cells with abnormally long cilia. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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