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Anti-KMT2D monoclonal antibody
Pre-made anti-KMT2D monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to KMT2D/KMT2D products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2567-Ab-1/ GM-Tg-hg-IP2567-Ab-2 | Anti-Human KMT2D monoclonal antibody | Human |
| GM-Tg-rg-IP2567-Ab-1/ GM-Tg-rg-IP2567-Ab-2 | Anti-Rat KMT2D monoclonal antibody | Rat |
| GM-Tg-mg-IP2567-Ab-1/ GM-Tg-mg-IP2567-Ab-2 | Anti-Mouse KMT2D monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2567-Ab-1/ GM-Tg-cynog-IP2567-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KMT2D monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2567-Ab-1/ GM-Tg-felg-IP2567-Ab-2 | Anti-Feline KMT2D monoclonal antibody | Feline |
| GM-Tg-cang-IP2567-Ab-1/ GM-Tg-cang-IP2567-Ab-2 | Anti-Canine KMT2D monoclonal antibody | Canine |
| GM-Tg-bovg-IP2567-Ab-1/ GM-Tg-bovg-IP2567-Ab-2 | Anti-Bovine KMT2D monoclonal antibody | Bovine |
| GM-Tg-equg-IP2567-Ab-1/ GM-Tg-equg-IP2567-Ab-2 | Anti-Equine KMT2D monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2567-Ab-1/ GM-Tg-hg-IP2567-Ab-2; GM-Tg-rg-IP2567-Ab-1/ GM-Tg-rg-IP2567-Ab-2; GM-Tg-mg-IP2567-Ab-1/ GM-Tg-mg-IP2567-Ab-2; GM-Tg-cynog-IP2567-Ab-1/ GM-Tg-cynog-IP2567-Ab-2; GM-Tg-felg-IP2567-Ab-1/ GM-Tg-felg-IP2567-Ab-2; GM-Tg-cang-IP2567-Ab-1/ GM-Tg-cang-IP2567-Ab-2; GM-Tg-bovg-IP2567-Ab-1/ GM-Tg-bovg-IP2567-Ab-2; GM-Tg-equg-IP2567-Ab-1/ GM-Tg-equg-IP2567-Ab-2 |
| Products Name | Anti-KMT2D monoclonal antibody |
| Format | mab |
| Target Name | KMT2D |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-KMT2D monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2567-Ag-1 | Recombinant multi-species KMT2D/ AAD10/ ALR protein |
Target information
| Target ID | GM-IP2567 |
| Target Name | KMT2D |
| Gene ID | 8085,381022,100362634,710795,486558,101095268,506805,100058932 |
| Gene Symbol and Synonyms | AAD10,ALR,BCAHH,C430014K11Rik,CAGL114,KABUK1,KMS,KMT2B,KMT2D,MLL2,MLL4,TNRC21 |
| Uniprot Accession | O14686 |
| Uniprot Entry Name | KMT2D_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000167548 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: KMT2D, gene name: KMT2D, also named as AAD10, ALR, CAGL114, KABUK1, KMS, MLL2, MLL4, TNRC21. The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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