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Anti-MAP2K4 monoclonal antibody
Pre-made anti-MAP2K4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MAP2K4/MAP2K4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2586-Ab-1/ GM-Tg-hg-IP2586-Ab-2 | Anti-Human MAP2K4 monoclonal antibody | Human |
| GM-Tg-rg-IP2586-Ab-1/ GM-Tg-rg-IP2586-Ab-2 | Anti-Rat MAP2K4 monoclonal antibody | Rat |
| GM-Tg-mg-IP2586-Ab-1/ GM-Tg-mg-IP2586-Ab-2 | Anti-Mouse MAP2K4 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2586-Ab-1/ GM-Tg-cynog-IP2586-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MAP2K4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2586-Ab-1/ GM-Tg-felg-IP2586-Ab-2 | Anti-Feline MAP2K4 monoclonal antibody | Feline |
| GM-Tg-cang-IP2586-Ab-1/ GM-Tg-cang-IP2586-Ab-2 | Anti-Canine MAP2K4 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2586-Ab-1/ GM-Tg-bovg-IP2586-Ab-2 | Anti-Bovine MAP2K4 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2586-Ab-1/ GM-Tg-equg-IP2586-Ab-2 | Anti-Equine MAP2K4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2586-Ab-1/ GM-Tg-hg-IP2586-Ab-2; GM-Tg-rg-IP2586-Ab-1/ GM-Tg-rg-IP2586-Ab-2; GM-Tg-mg-IP2586-Ab-1/ GM-Tg-mg-IP2586-Ab-2; GM-Tg-cynog-IP2586-Ab-1/ GM-Tg-cynog-IP2586-Ab-2; GM-Tg-felg-IP2586-Ab-1/ GM-Tg-felg-IP2586-Ab-2; GM-Tg-cang-IP2586-Ab-1/ GM-Tg-cang-IP2586-Ab-2; GM-Tg-bovg-IP2586-Ab-1/ GM-Tg-bovg-IP2586-Ab-2; GM-Tg-equg-IP2586-Ab-1/ GM-Tg-equg-IP2586-Ab-2 |
| Products Name | Anti-MAP2K4 monoclonal antibody |
| Format | mab |
| Target Name | MAP2K4 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MAP2K4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2586-Ag-1 | Recombinant multi-species MP2K4/ MAP2K4/ JNKK protein |
| ORF Viral Vector | pGMLPm002491 | mouse Map2k4 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002492 | mouse Map2k4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002491 | mouse Map2k4 Lentivirus particle |
| ORF Viral Vector | vGMLPm002492 | mouse Map2k4 Lentivirus particle |
Target information
| Target ID | GM-IP2586 |
| Target Name | MAP2K4 |
| Gene ID | 6416,26398,287398,718155,489508,101086432,526469,100073094 |
| Gene Symbol and Synonyms | JNKK,JNKK1,MAP2K4,MAPKK 4,MAPKK4,MEK4,MKK4,PRKMK4,SAPKK-1,SAPKK1,SEK1,SERK1,SKK1 |
| Uniprot Accession | P45985 |
| Uniprot Entry Name | MP2K4_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000065559 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: MAP2K4, gene name: MAP2K4, also named as JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1. This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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