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Anti-MAP4K5 monoclonal antibody
Pre-made anti-MAP4K5 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MAP4K5/MAP4K5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2587-Ab-1/ GM-Tg-hg-IP2587-Ab-2 | Anti-Human MAP4K5 monoclonal antibody | Human |
| GM-Tg-rg-IP2587-Ab-1/ GM-Tg-rg-IP2587-Ab-2 | Anti-Rat MAP4K5 monoclonal antibody | Rat |
| GM-Tg-mg-IP2587-Ab-1/ GM-Tg-mg-IP2587-Ab-2 | Anti-Mouse MAP4K5 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2587-Ab-1/ GM-Tg-cynog-IP2587-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MAP4K5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2587-Ab-1/ GM-Tg-felg-IP2587-Ab-2 | Anti-Feline MAP4K5 monoclonal antibody | Feline |
| GM-Tg-cang-IP2587-Ab-1/ GM-Tg-cang-IP2587-Ab-2 | Anti-Canine MAP4K5 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2587-Ab-1/ GM-Tg-bovg-IP2587-Ab-2 | Anti-Bovine MAP4K5 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2587-Ab-1/ GM-Tg-equg-IP2587-Ab-2 | Anti-Equine MAP4K5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2587-Ab-1/ GM-Tg-hg-IP2587-Ab-2; GM-Tg-rg-IP2587-Ab-1/ GM-Tg-rg-IP2587-Ab-2; GM-Tg-mg-IP2587-Ab-1/ GM-Tg-mg-IP2587-Ab-2; GM-Tg-cynog-IP2587-Ab-1/ GM-Tg-cynog-IP2587-Ab-2; GM-Tg-felg-IP2587-Ab-1/ GM-Tg-felg-IP2587-Ab-2; GM-Tg-cang-IP2587-Ab-1/ GM-Tg-cang-IP2587-Ab-2; GM-Tg-bovg-IP2587-Ab-1/ GM-Tg-bovg-IP2587-Ab-2; GM-Tg-equg-IP2587-Ab-1/ GM-Tg-equg-IP2587-Ab-2 |
| Products Name | Anti-MAP4K5 monoclonal antibody |
| Format | mab |
| Target Name | MAP4K5 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MAP4K5 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2587-Ag-1 | Recombinant multi-species M4K5/ MAP4K5/ GCKR protein |
| ORF Viral Vector | pGMLPm003586 | mouse Map4k5 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003586 | mouse Map4k5 Lentivirus particle |
Target information
| Target ID | GM-IP2587 |
| Target Name | MAP4K5 |
| Gene ID | 11183,399510,503027,706204,490685,101095501,781335,100066454 |
| Gene Symbol and Synonyms | 4432415E19Rik,GCKR,KHS,KHS1,MAP4K5,MAPKKKK5,RGD1562028 |
| Uniprot Accession | Q9Y4K4 |
| Uniprot Entry Name | M4K5_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000012983 |
| Target Classification | Kinase |
The target: MAP4K5, gene name: MAP4K5, also named as GCKR, KHS, KHS1, MAPKKKK5. This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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