Anti-MTHFR monoclonal antibody

Pre-made anti-MTHFR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to MTHFR/MTHFR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP2611-Ab-1/ GM-Tg-hg-IP2611-Ab-2Anti-Human MTHFR monoclonal antibodyHuman
GM-Tg-rg-IP2611-Ab-1/ GM-Tg-rg-IP2611-Ab-2Anti-Rat MTHFR monoclonal antibodyRat
GM-Tg-mg-IP2611-Ab-1/ GM-Tg-mg-IP2611-Ab-2Anti-Mouse MTHFR monoclonal antibodyMouse
GM-Tg-cynog-IP2611-Ab-1/ GM-Tg-cynog-IP2611-Ab-2Anti-Cynomolgus/ Rhesus macaque MTHFR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP2611-Ab-1/ GM-Tg-felg-IP2611-Ab-2Anti-Feline MTHFR monoclonal antibodyFeline
GM-Tg-cang-IP2611-Ab-1/ GM-Tg-cang-IP2611-Ab-2Anti-Canine MTHFR monoclonal antibodyCanine
GM-Tg-bovg-IP2611-Ab-1/ GM-Tg-bovg-IP2611-Ab-2Anti-Bovine MTHFR monoclonal antibodyBovine
GM-Tg-equg-IP2611-Ab-1/ GM-Tg-equg-IP2611-Ab-2Anti-Equine MTHFR monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP2611-Ab-1/ GM-Tg-hg-IP2611-Ab-2; GM-Tg-rg-IP2611-Ab-1/ GM-Tg-rg-IP2611-Ab-2;
GM-Tg-mg-IP2611-Ab-1/ GM-Tg-mg-IP2611-Ab-2; GM-Tg-cynog-IP2611-Ab-1/ GM-Tg-cynog-IP2611-Ab-2;
GM-Tg-felg-IP2611-Ab-1/ GM-Tg-felg-IP2611-Ab-2; GM-Tg-cang-IP2611-Ab-1/ GM-Tg-cang-IP2611-Ab-2;
GM-Tg-bovg-IP2611-Ab-1/ GM-Tg-bovg-IP2611-Ab-2; GM-Tg-equg-IP2611-Ab-1/ GM-Tg-equg-IP2611-Ab-2
Products NameAnti-MTHFR monoclonal antibody
Formatmab
Target NameMTHFR
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-MTHFR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP2611-Ag-1Recombinant multi-species MTHR/ MTHFR protein


    Target information

    Target IDGM-IP2611
    Target NameMTHFR
    Gene ID4524,17769,362657,714840,478230,101100576,497032,100050979
    Gene Symbol and SynonymsMTHFR
    Uniprot AccessionP42898,Q5I598
    Uniprot Entry NameMTHR_HUMAN,MTHR_BOVIN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseLung Cancer
    Gene EnsemblENSG00000177000
    Target ClassificationN/A

    The target: MTHFR, gene name: MTHFR, also named as . The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.