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Anti-NUS1 monoclonal antibody
Pre-made anti-NUS1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to NUS1/NUS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2634-Ab-1/ GM-Tg-hg-IP2634-Ab-2 | Anti-Human NUS1 monoclonal antibody | Human |
| GM-Tg-rg-IP2634-Ab-1/ GM-Tg-rg-IP2634-Ab-2 | Anti-Rat NUS1 monoclonal antibody | Rat |
| GM-Tg-mg-IP2634-Ab-1/ GM-Tg-mg-IP2634-Ab-2 | Anti-Mouse NUS1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2634-Ab-1/ GM-Tg-cynog-IP2634-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NUS1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2634-Ab-1/ GM-Tg-felg-IP2634-Ab-2 | Anti-Feline NUS1 monoclonal antibody | Feline |
| GM-Tg-cang-IP2634-Ab-1/ GM-Tg-cang-IP2634-Ab-2 | Anti-Canine NUS1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2634-Ab-1/ GM-Tg-bovg-IP2634-Ab-2 | Anti-Bovine NUS1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2634-Ab-1/ GM-Tg-equg-IP2634-Ab-2 | Anti-Equine NUS1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2634-Ab-1/ GM-Tg-hg-IP2634-Ab-2; GM-Tg-rg-IP2634-Ab-1/ GM-Tg-rg-IP2634-Ab-2; GM-Tg-mg-IP2634-Ab-1/ GM-Tg-mg-IP2634-Ab-2; GM-Tg-cynog-IP2634-Ab-1/ GM-Tg-cynog-IP2634-Ab-2; GM-Tg-felg-IP2634-Ab-1/ GM-Tg-felg-IP2634-Ab-2; GM-Tg-cang-IP2634-Ab-1/ GM-Tg-cang-IP2634-Ab-2; GM-Tg-bovg-IP2634-Ab-1/ GM-Tg-bovg-IP2634-Ab-2; GM-Tg-equg-IP2634-Ab-1/ GM-Tg-equg-IP2634-Ab-2 |
| Products Name | Anti-NUS1 monoclonal antibody |
| Format | mab |
| Target Name | NUS1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-NUS1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2634-Ag-1 | Recombinant multi-species NGBR/ NUS1/ C6orf68 protein |
| ORF Viral Vector | pGMLP005034 | human NUS1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP005034 | human NUS1 Lentivirus particle |
| ORF Viral Vector | pGMAAV000205 | house mouse Nus1 AAV plasmid |
| ORF Viral Vector | vGMAAV000205 | house mouse Nus1 AAV particle |
Target information
| Target ID | GM-IP2634 |
| Target Name | NUS1 |
| Gene ID | 116150,52014,294400,715015,484102,101094180,100849670,100067138 |
| Gene Symbol and Synonyms | 1600027K07Rik,C6orf68,CDG1AA,D10Ertd438e,MGC:7199,MRD55,NgBR,NUS1,RGD1307879,TANGO14 |
| Uniprot Accession | Q96E22 |
| Uniprot Entry Name | NGBR_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000153989 |
| Target Classification | N/A |
The target: NUS1, gene name: NUS1, also named as C6orf68, CDG1AA, MGC:7199, MRD55, NgBR, TANGO14. This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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