Anti-PLEKHG4 monoclonal antibody

Pre-made anti-PLEKHG4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to PLEKHG4/PLEKHG4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP2660-Ab-1/ GM-Tg-hg-IP2660-Ab-2Anti-Human PLEKHG4 monoclonal antibodyHuman
GM-Tg-rg-IP2660-Ab-1/ GM-Tg-rg-IP2660-Ab-2Anti-Rat PLEKHG4 monoclonal antibodyRat
GM-Tg-mg-IP2660-Ab-1/ GM-Tg-mg-IP2660-Ab-2Anti-Mouse PLEKHG4 monoclonal antibodyMouse
GM-Tg-cynog-IP2660-Ab-1/ GM-Tg-cynog-IP2660-Ab-2Anti-Cynomolgus/ Rhesus macaque PLEKHG4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP2660-Ab-1/ GM-Tg-felg-IP2660-Ab-2Anti-Feline PLEKHG4 monoclonal antibodyFeline
GM-Tg-cang-IP2660-Ab-1/ GM-Tg-cang-IP2660-Ab-2Anti-Canine PLEKHG4 monoclonal antibodyCanine
GM-Tg-bovg-IP2660-Ab-1/ GM-Tg-bovg-IP2660-Ab-2Anti-Bovine PLEKHG4 monoclonal antibodyBovine
GM-Tg-equg-IP2660-Ab-1/ GM-Tg-equg-IP2660-Ab-2Anti-Equine PLEKHG4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP2660-Ab-1/ GM-Tg-hg-IP2660-Ab-2; GM-Tg-rg-IP2660-Ab-1/ GM-Tg-rg-IP2660-Ab-2;
GM-Tg-mg-IP2660-Ab-1/ GM-Tg-mg-IP2660-Ab-2; GM-Tg-cynog-IP2660-Ab-1/ GM-Tg-cynog-IP2660-Ab-2;
GM-Tg-felg-IP2660-Ab-1/ GM-Tg-felg-IP2660-Ab-2; GM-Tg-cang-IP2660-Ab-1/ GM-Tg-cang-IP2660-Ab-2;
GM-Tg-bovg-IP2660-Ab-1/ GM-Tg-bovg-IP2660-Ab-2; GM-Tg-equg-IP2660-Ab-1/ GM-Tg-equg-IP2660-Ab-2
Products NameAnti-PLEKHG4 monoclonal antibody
Formatmab
Target NamePLEKHG4
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-PLEKHG4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP2660-Ag-1Recombinant multi-species PKHG4/ PLEKHG4/ ARHGEF44 protein


    Target information

    Target IDGM-IP2660
    Target NamePLEKHG4
    Gene ID25894,102075,307796,699160,489759,101089062,787892,100065930
    Gene Symbol and Synonyms4931414L13Rik,ARHGEF44,PLEKHG4,PRTPHN1,RGD1310790,SCA4
    Uniprot AccessionQ58EX7
    Uniprot Entry NamePKHG4_HUMAN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000196155
    Target ClassificationN/A

    The target: PLEKHG4, gene name: PLEKHG4, also named as ARHGEF44, PRTPHN1, SCA4. The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.