- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-PPP1R12B monoclonal antibody
Pre-made anti-PPP1R12B monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PPP1R12B/PPP1R12B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2665-Ab-1/ GM-Tg-hg-IP2665-Ab-2 | Anti-Human PPP1R12B monoclonal antibody | Human |
| GM-Tg-rg-IP2665-Ab-1/ GM-Tg-rg-IP2665-Ab-2 | Anti-Rat PPP1R12B monoclonal antibody | Rat |
| GM-Tg-mg-IP2665-Ab-1/ GM-Tg-mg-IP2665-Ab-2 | Anti-Mouse PPP1R12B monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2665-Ab-1/ GM-Tg-cynog-IP2665-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PPP1R12B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2665-Ab-1/ GM-Tg-felg-IP2665-Ab-2 | Anti-Feline PPP1R12B monoclonal antibody | Feline |
| GM-Tg-cang-IP2665-Ab-1/ GM-Tg-cang-IP2665-Ab-2 | Anti-Canine PPP1R12B monoclonal antibody | Canine |
| GM-Tg-bovg-IP2665-Ab-1/ GM-Tg-bovg-IP2665-Ab-2 | Anti-Bovine PPP1R12B monoclonal antibody | Bovine |
| GM-Tg-equg-IP2665-Ab-1/ GM-Tg-equg-IP2665-Ab-2 | Anti-Equine PPP1R12B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2665-Ab-1/ GM-Tg-hg-IP2665-Ab-2; GM-Tg-rg-IP2665-Ab-1/ GM-Tg-rg-IP2665-Ab-2; GM-Tg-mg-IP2665-Ab-1/ GM-Tg-mg-IP2665-Ab-2; GM-Tg-cynog-IP2665-Ab-1/ GM-Tg-cynog-IP2665-Ab-2; GM-Tg-felg-IP2665-Ab-1/ GM-Tg-felg-IP2665-Ab-2; GM-Tg-cang-IP2665-Ab-1/ GM-Tg-cang-IP2665-Ab-2; GM-Tg-bovg-IP2665-Ab-1/ GM-Tg-bovg-IP2665-Ab-2; GM-Tg-equg-IP2665-Ab-1/ GM-Tg-equg-IP2665-Ab-2 |
| Products Name | Anti-PPP1R12B monoclonal antibody |
| Format | mab |
| Target Name | PPP1R12B |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PPP1R12B monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2665-Ag-1 | Recombinant multi-species MYPT2/ PPP1R12B/ PP1bp55 protein |
Target information
| Target ID | GM-IP2665 |
| Target Name | PPP1R12B |
| Gene ID | 4660,329251,304813,705775,490230,101098766,107131237,100063928 |
| Gene Symbol and Synonyms | 1810037O03Rik,9530009M10Rik,MYPT2,PP1bp55,PPP1R12B |
| Uniprot Accession | O60237 |
| Uniprot Entry Name | MYPT2_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000077157 |
| Target Classification | N/A |
The target: PPP1R12B, gene name: PPP1R12B, also named as MYPT2, PP1bp55. Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
