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Anti-PPP2R1B monoclonal antibody
Pre-made anti-PPP2R1B monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PPP2R1B/PPP2R1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2668-Ab-1/ GM-Tg-hg-IP2668-Ab-2 | Anti-Human PPP2R1B monoclonal antibody | Human |
| GM-Tg-rg-IP2668-Ab-1/ GM-Tg-rg-IP2668-Ab-2 | Anti-Rat PPP2R1B monoclonal antibody | Rat |
| GM-Tg-mg-IP2668-Ab-1/ GM-Tg-mg-IP2668-Ab-2 | Anti-Mouse PPP2R1B monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2668-Ab-1/ GM-Tg-cynog-IP2668-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PPP2R1B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2668-Ab-1/ GM-Tg-felg-IP2668-Ab-2 | Anti-Feline PPP2R1B monoclonal antibody | Feline |
| GM-Tg-cang-IP2668-Ab-1/ GM-Tg-cang-IP2668-Ab-2 | Anti-Canine PPP2R1B monoclonal antibody | Canine |
| GM-Tg-bovg-IP2668-Ab-1/ GM-Tg-bovg-IP2668-Ab-2 | Anti-Bovine PPP2R1B monoclonal antibody | Bovine |
| GM-Tg-equg-IP2668-Ab-1/ GM-Tg-equg-IP2668-Ab-2 | Anti-Equine PPP2R1B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2668-Ab-1/ GM-Tg-hg-IP2668-Ab-2; GM-Tg-rg-IP2668-Ab-1/ GM-Tg-rg-IP2668-Ab-2; GM-Tg-mg-IP2668-Ab-1/ GM-Tg-mg-IP2668-Ab-2; GM-Tg-cynog-IP2668-Ab-1/ GM-Tg-cynog-IP2668-Ab-2; GM-Tg-felg-IP2668-Ab-1/ GM-Tg-felg-IP2668-Ab-2; GM-Tg-cang-IP2668-Ab-1/ GM-Tg-cang-IP2668-Ab-2; GM-Tg-bovg-IP2668-Ab-1/ GM-Tg-bovg-IP2668-Ab-2; GM-Tg-equg-IP2668-Ab-1/ GM-Tg-equg-IP2668-Ab-2 |
| Products Name | Anti-PPP2R1B monoclonal antibody |
| Format | mab |
| Target Name | PPP2R1B |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PPP2R1B monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2668-Ag-1 | Recombinant multi-species 2AAB/ PPP2R1B/ PP2A-Abeta protein |
| ORF Viral Vector | pGMLP003298 | human PPP2R1B Lentivirus plasmid |
| ORF Viral Vector | vGMLP003298 | human PPP2R1B Lentivirus particle |
Target information
| Target ID | GM-IP2668 |
| Target Name | PPP2R1B |
| Gene ID | 5519,73699,315648,710387,479444,101081075,100138150,100070408 |
| Gene Symbol and Synonyms | 2410091N08Rik,PP2A-Abeta,PPP2R1B,PR65B |
| Uniprot Accession | P30154,Q4QQT4 |
| Uniprot Entry Name | 2AAB_HUMAN,2AAB_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000137713 |
| Target Classification | N/A |
The target: PPP2R1B, gene name: PPP2R1B, also named as PP2A-Abeta, PR65B. This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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