Anti-PSMC5 monoclonal antibody

Pre-made anti-PSMC5 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to PSMC5/PSMC5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP2675-Ab-1/ GM-Tg-hg-IP2675-Ab-2Anti-Human PSMC5 monoclonal antibodyHuman
GM-Tg-rg-IP2675-Ab-1/ GM-Tg-rg-IP2675-Ab-2Anti-Rat PSMC5 monoclonal antibodyRat
GM-Tg-mg-IP2675-Ab-1/ GM-Tg-mg-IP2675-Ab-2Anti-Mouse PSMC5 monoclonal antibodyMouse
GM-Tg-cynog-IP2675-Ab-1/ GM-Tg-cynog-IP2675-Ab-2Anti-Cynomolgus/ Rhesus macaque PSMC5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP2675-Ab-1/ GM-Tg-felg-IP2675-Ab-2Anti-Feline PSMC5 monoclonal antibodyFeline
GM-Tg-cang-IP2675-Ab-1/ GM-Tg-cang-IP2675-Ab-2Anti-Canine PSMC5 monoclonal antibodyCanine
GM-Tg-bovg-IP2675-Ab-1/ GM-Tg-bovg-IP2675-Ab-2Anti-Bovine PSMC5 monoclonal antibodyBovine
GM-Tg-equg-IP2675-Ab-1/ GM-Tg-equg-IP2675-Ab-2Anti-Equine PSMC5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP2675-Ab-1/ GM-Tg-hg-IP2675-Ab-2; GM-Tg-rg-IP2675-Ab-1/ GM-Tg-rg-IP2675-Ab-2;
GM-Tg-mg-IP2675-Ab-1/ GM-Tg-mg-IP2675-Ab-2; GM-Tg-cynog-IP2675-Ab-1/ GM-Tg-cynog-IP2675-Ab-2;
GM-Tg-felg-IP2675-Ab-1/ GM-Tg-felg-IP2675-Ab-2; GM-Tg-cang-IP2675-Ab-1/ GM-Tg-cang-IP2675-Ab-2;
GM-Tg-bovg-IP2675-Ab-1/ GM-Tg-bovg-IP2675-Ab-2; GM-Tg-equg-IP2675-Ab-1/ GM-Tg-equg-IP2675-Ab-2
Products NameAnti-PSMC5 monoclonal antibody
Formatmab
Target NamePSMC5
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-PSMC5 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP2675-Ag-1Recombinant multi-species PRS8/ PSMC5/ S8 protein


    Target information

    Target IDGM-IP2675
    Target NamePSMC5
    Gene ID5705,19184,81827,717437,480478,101097360,282015,100053987
    Gene Symbol and SynonymsmSUG1,p45,p45/SUG,PSMC5,RPT6,S8,SUG-1,SUG1,TBP10,TRIP1
    Uniprot AccessionP62195,P62198,P62194
    Uniprot Entry NamePRS8_HUMAN,PRS8_RAT,PRS8_BOVIN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000087191
    Target ClassificationN/A

    The target: PSMC5, gene name: PSMC5, also named as S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.