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Anti-PTPN12 monoclonal antibody
Pre-made anti-PTPN12 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PTPN12/PTPN12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2678-Ab-1/ GM-Tg-hg-IP2678-Ab-2 | Anti-Human PTPN12 monoclonal antibody | Human |
| GM-Tg-rg-IP2678-Ab-1/ GM-Tg-rg-IP2678-Ab-2 | Anti-Rat PTPN12 monoclonal antibody | Rat |
| GM-Tg-mg-IP2678-Ab-1/ GM-Tg-mg-IP2678-Ab-2 | Anti-Mouse PTPN12 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2678-Ab-1/ GM-Tg-cynog-IP2678-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTPN12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2678-Ab-1/ GM-Tg-felg-IP2678-Ab-2 | Anti-Feline PTPN12 monoclonal antibody | Feline |
| GM-Tg-cang-IP2678-Ab-1/ GM-Tg-cang-IP2678-Ab-2 | Anti-Canine PTPN12 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2678-Ab-1/ GM-Tg-bovg-IP2678-Ab-2 | Anti-Bovine PTPN12 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2678-Ab-1/ GM-Tg-equg-IP2678-Ab-2 | Anti-Equine PTPN12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2678-Ab-1/ GM-Tg-hg-IP2678-Ab-2; GM-Tg-rg-IP2678-Ab-1/ GM-Tg-rg-IP2678-Ab-2; GM-Tg-mg-IP2678-Ab-1/ GM-Tg-mg-IP2678-Ab-2; GM-Tg-cynog-IP2678-Ab-1/ GM-Tg-cynog-IP2678-Ab-2; GM-Tg-felg-IP2678-Ab-1/ GM-Tg-felg-IP2678-Ab-2; GM-Tg-cang-IP2678-Ab-1/ GM-Tg-cang-IP2678-Ab-2; GM-Tg-bovg-IP2678-Ab-1/ GM-Tg-bovg-IP2678-Ab-2; GM-Tg-equg-IP2678-Ab-1/ GM-Tg-equg-IP2678-Ab-2 |
| Products Name | Anti-PTPN12 monoclonal antibody |
| Format | mab |
| Target Name | PTPN12 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PTPN12 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2678-Ag-1 | Recombinant multi-species PTN12/ PTPN12/ PTP-PEST protein |
| ORF Viral Vector | vGMLP001336 | human PTPN12 Lentivirus particle |
| ORF Viral Vector | pGMLP001336 | human PTPN12 Lentivirus plasmid |
Target information
| Target ID | GM-IP2678 |
| Target Name | PTPN12 |
| Gene ID | 5782,19248,117255,721538,483277,101091096,531877,100057833 |
| Gene Symbol and Synonyms | P19-PTP,PTP-P19,PTP-PEST,PTPG1,PTPN12,RKPTP |
| Uniprot Accession | Q05209 |
| Uniprot Entry Name | PTN12_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000127947 |
| Target Classification | N/A |
The target: PTPN12, gene name: PTPN12, also named as PTP-PEST, PTPG1. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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