- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-PTPN21 monoclonal antibody
Pre-made anti-PTPN21 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PTPN21/PTPN21 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2679-Ab-1/ GM-Tg-hg-IP2679-Ab-2 | Anti-Human PTPN21 monoclonal antibody | Human |
| GM-Tg-rg-IP2679-Ab-1/ GM-Tg-rg-IP2679-Ab-2 | Anti-Rat PTPN21 monoclonal antibody | Rat |
| GM-Tg-mg-IP2679-Ab-1/ GM-Tg-mg-IP2679-Ab-2 | Anti-Mouse PTPN21 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2679-Ab-1/ GM-Tg-cynog-IP2679-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTPN21 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2679-Ab-1/ GM-Tg-felg-IP2679-Ab-2 | Anti-Feline PTPN21 monoclonal antibody | Feline |
| GM-Tg-cang-IP2679-Ab-1/ GM-Tg-cang-IP2679-Ab-2 | Anti-Canine PTPN21 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2679-Ab-1/ GM-Tg-bovg-IP2679-Ab-2 | Anti-Bovine PTPN21 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2679-Ab-1/ GM-Tg-equg-IP2679-Ab-2 | Anti-Equine PTPN21 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2679-Ab-1/ GM-Tg-hg-IP2679-Ab-2; GM-Tg-rg-IP2679-Ab-1/ GM-Tg-rg-IP2679-Ab-2; GM-Tg-mg-IP2679-Ab-1/ GM-Tg-mg-IP2679-Ab-2; GM-Tg-cynog-IP2679-Ab-1/ GM-Tg-cynog-IP2679-Ab-2; GM-Tg-felg-IP2679-Ab-1/ GM-Tg-felg-IP2679-Ab-2; GM-Tg-cang-IP2679-Ab-1/ GM-Tg-cang-IP2679-Ab-2; GM-Tg-bovg-IP2679-Ab-1/ GM-Tg-bovg-IP2679-Ab-2; GM-Tg-equg-IP2679-Ab-1/ GM-Tg-equg-IP2679-Ab-2 |
| Products Name | Anti-PTPN21 monoclonal antibody |
| Format | mab |
| Target Name | PTPN21 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PTPN21 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2679-Ag-1 | Recombinant multi-species PTN21/ PTPN21/ PTPD1 protein |
Target information
| Target ID | GM-IP2679 |
| Target Name | PTPN21 |
| Gene ID | 11099,24000,171070,693960,490823,101084369,520178,100062018 |
| Gene Symbol and Synonyms | Ptp2E,PTPD1,PTPN21,PTPRL10 |
| Uniprot Accession | Q16825,Q62728 |
| Uniprot Entry Name | PTN21_HUMAN,PTN21_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000070778 |
| Target Classification | N/A |
The target: PTPN21, gene name: PTPN21, also named as PTPD1, PTPRL10. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
