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Anti-SHANK3 monoclonal antibody
Pre-made anti-SHANK3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SHANK3/SHANK3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2737-Ab-1/ GM-Tg-hg-IP2737-Ab-2 | Anti-Human SHANK3 monoclonal antibody | Human |
| GM-Tg-rg-IP2737-Ab-1/ GM-Tg-rg-IP2737-Ab-2 | Anti-Rat SHANK3 monoclonal antibody | Rat |
| GM-Tg-mg-IP2737-Ab-1/ GM-Tg-mg-IP2737-Ab-2 | Anti-Mouse SHANK3 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2737-Ab-1/ GM-Tg-cynog-IP2737-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SHANK3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2737-Ab-1/ GM-Tg-felg-IP2737-Ab-2 | Anti-Feline SHANK3 monoclonal antibody | Feline |
| GM-Tg-cang-IP2737-Ab-1/ GM-Tg-cang-IP2737-Ab-2 | Anti-Canine SHANK3 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2737-Ab-1/ GM-Tg-bovg-IP2737-Ab-2 | Anti-Bovine SHANK3 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2737-Ab-1/ GM-Tg-equg-IP2737-Ab-2 | Anti-Equine SHANK3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2737-Ab-1/ GM-Tg-hg-IP2737-Ab-2; GM-Tg-rg-IP2737-Ab-1/ GM-Tg-rg-IP2737-Ab-2; GM-Tg-mg-IP2737-Ab-1/ GM-Tg-mg-IP2737-Ab-2; GM-Tg-cynog-IP2737-Ab-1/ GM-Tg-cynog-IP2737-Ab-2; GM-Tg-felg-IP2737-Ab-1/ GM-Tg-felg-IP2737-Ab-2; GM-Tg-cang-IP2737-Ab-1/ GM-Tg-cang-IP2737-Ab-2; GM-Tg-bovg-IP2737-Ab-1/ GM-Tg-bovg-IP2737-Ab-2; GM-Tg-equg-IP2737-Ab-1/ GM-Tg-equg-IP2737-Ab-2 |
| Products Name | Anti-SHANK3 monoclonal antibody |
| Format | mab |
| Target Name | SHANK3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SHANK3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2737-Ag-1 | Recombinant multi-species SHAN3/ SHANK3/ DEL22q13.3 protein |
| ORF Viral Vector | pGMAD000307 | mouse Shank3 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000307 | mouse Shank3 Adenovirus particle |
Target information
| Target ID | GM-IP2737 |
| Target Name | SHANK3 |
| Gene ID | 85358,58234,59312,100430318,474456,101085990,512428,100056993 |
| Gene Symbol and Synonyms | DEL22q13.3,PROSAP2,PSAP2,SCZD15,SHANK3,SPANK-2 |
| Uniprot Accession | Q9BYB0,Q9JLU4 |
| Uniprot Entry Name | SHAN3_HUMAN,SHAN3_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000251322 |
| Target Classification | N/A |
The target: SHANK3, gene name: SHANK3, also named as DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2. This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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