Anti-SIPA1 monoclonal antibody

Pre-made anti-SIPA1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to SIPA1/SIPA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP2741-Ab-1/ GM-Tg-hg-IP2741-Ab-2Anti-Human SIPA1 monoclonal antibodyHuman
GM-Tg-rg-IP2741-Ab-1/ GM-Tg-rg-IP2741-Ab-2Anti-Rat SIPA1 monoclonal antibodyRat
GM-Tg-mg-IP2741-Ab-1/ GM-Tg-mg-IP2741-Ab-2Anti-Mouse SIPA1 monoclonal antibodyMouse
GM-Tg-cynog-IP2741-Ab-1/ GM-Tg-cynog-IP2741-Ab-2Anti-Cynomolgus/ Rhesus macaque SIPA1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP2741-Ab-1/ GM-Tg-felg-IP2741-Ab-2Anti-Feline SIPA1 monoclonal antibodyFeline
GM-Tg-cang-IP2741-Ab-1/ GM-Tg-cang-IP2741-Ab-2Anti-Canine SIPA1 monoclonal antibodyCanine
GM-Tg-bovg-IP2741-Ab-1/ GM-Tg-bovg-IP2741-Ab-2Anti-Bovine SIPA1 monoclonal antibodyBovine
GM-Tg-equg-IP2741-Ab-1/ GM-Tg-equg-IP2741-Ab-2Anti-Equine SIPA1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP2741-Ab-1/ GM-Tg-hg-IP2741-Ab-2; GM-Tg-rg-IP2741-Ab-1/ GM-Tg-rg-IP2741-Ab-2;
GM-Tg-mg-IP2741-Ab-1/ GM-Tg-mg-IP2741-Ab-2; GM-Tg-cynog-IP2741-Ab-1/ GM-Tg-cynog-IP2741-Ab-2;
GM-Tg-felg-IP2741-Ab-1/ GM-Tg-felg-IP2741-Ab-2; GM-Tg-cang-IP2741-Ab-1/ GM-Tg-cang-IP2741-Ab-2;
GM-Tg-bovg-IP2741-Ab-1/ GM-Tg-bovg-IP2741-Ab-2; GM-Tg-equg-IP2741-Ab-1/ GM-Tg-equg-IP2741-Ab-2
Products NameAnti-SIPA1 monoclonal antibody
Formatmab
Target NameSIPA1
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-SIPA1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP2741-Ag-1Recombinant multi-species SIPA1/ SPA1 protein


    Target information

    Target IDGM-IP2741
    Target NameSIPA1
    Gene ID6494,20469,361710,715958,483730,101099149,508234,100057444
    Gene Symbol and SynonymsSIPA1,SPA1
    Uniprot AccessionQ96FS4
    Uniprot Entry NameSIPA1_HUMAN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseIgA glomerulonephritis
    Gene EnsemblENSG00000213445
    Target ClassificationN/A

    The target: SIPA1, gene name: SIPA1, also named as SPA1. The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.