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Anti-STIL monoclonal antibody
Pre-made anti-STIL monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to STIL/STIL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2758-Ab-1/ GM-Tg-hg-IP2758-Ab-2 | Anti-Human STIL monoclonal antibody | Human |
| GM-Tg-rg-IP2758-Ab-1/ GM-Tg-rg-IP2758-Ab-2 | Anti-Rat STIL monoclonal antibody | Rat |
| GM-Tg-mg-IP2758-Ab-1/ GM-Tg-mg-IP2758-Ab-2 | Anti-Mouse STIL monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2758-Ab-1/ GM-Tg-cynog-IP2758-Ab-2 | Anti-Cynomolgus/ Rhesus macaque STIL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2758-Ab-1/ GM-Tg-felg-IP2758-Ab-2 | Anti-Feline STIL monoclonal antibody | Feline |
| GM-Tg-cang-IP2758-Ab-1/ GM-Tg-cang-IP2758-Ab-2 | Anti-Canine STIL monoclonal antibody | Canine |
| GM-Tg-bovg-IP2758-Ab-1/ GM-Tg-bovg-IP2758-Ab-2 | Anti-Bovine STIL monoclonal antibody | Bovine |
| GM-Tg-equg-IP2758-Ab-1/ GM-Tg-equg-IP2758-Ab-2 | Anti-Equine STIL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2758-Ab-1/ GM-Tg-hg-IP2758-Ab-2; GM-Tg-rg-IP2758-Ab-1/ GM-Tg-rg-IP2758-Ab-2; GM-Tg-mg-IP2758-Ab-1/ GM-Tg-mg-IP2758-Ab-2; GM-Tg-cynog-IP2758-Ab-1/ GM-Tg-cynog-IP2758-Ab-2; GM-Tg-felg-IP2758-Ab-1/ GM-Tg-felg-IP2758-Ab-2; GM-Tg-cang-IP2758-Ab-1/ GM-Tg-cang-IP2758-Ab-2; GM-Tg-bovg-IP2758-Ab-1/ GM-Tg-bovg-IP2758-Ab-2; GM-Tg-equg-IP2758-Ab-1/ GM-Tg-equg-IP2758-Ab-2 |
| Products Name | Anti-STIL monoclonal antibody |
| Format | mab |
| Target Name | STIL |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-STIL monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2758-Ag-1 | Recombinant multi-species STIL/ MCPH7/ SIL protein |
Target information
| Target ID | GM-IP2758 |
| Target Name | STIL |
| Gene ID | 6491,20460,313506,710099,610305,101097659,510012,100051410 |
| Gene Symbol and Synonyms | MCPH7,SIL,STIL |
| Uniprot Accession | Q15468 |
| Uniprot Entry Name | STIL_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000123473 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: STIL, gene name: STIL, also named as MCPH7, SIL. This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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