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Anti-UBE2D1 monoclonal antibody
Pre-made anti-UBE2D1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to UBE2D1/UBE2D1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2795-Ab-1/ GM-Tg-hg-IP2795-Ab-2 | Anti-Human UBE2D1 monoclonal antibody | Human |
| GM-Tg-rg-IP2795-Ab-1/ GM-Tg-rg-IP2795-Ab-2 | Anti-Rat UBE2D1 monoclonal antibody | Rat |
| GM-Tg-mg-IP2795-Ab-1/ GM-Tg-mg-IP2795-Ab-2 | Anti-Mouse UBE2D1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2795-Ab-1/ GM-Tg-cynog-IP2795-Ab-2 | Anti-Cynomolgus/ Rhesus macaque UBE2D1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2795-Ab-1/ GM-Tg-felg-IP2795-Ab-2 | Anti-Feline UBE2D1 monoclonal antibody | Feline |
| GM-Tg-cang-IP2795-Ab-1/ GM-Tg-cang-IP2795-Ab-2 | Anti-Canine UBE2D1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2795-Ab-1/ GM-Tg-bovg-IP2795-Ab-2 | Anti-Bovine UBE2D1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2795-Ab-1/ GM-Tg-equg-IP2795-Ab-2 | Anti-Equine UBE2D1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2795-Ab-1/ GM-Tg-hg-IP2795-Ab-2; GM-Tg-rg-IP2795-Ab-1/ GM-Tg-rg-IP2795-Ab-2; GM-Tg-mg-IP2795-Ab-1/ GM-Tg-mg-IP2795-Ab-2; GM-Tg-cynog-IP2795-Ab-1/ GM-Tg-cynog-IP2795-Ab-2; GM-Tg-felg-IP2795-Ab-1/ GM-Tg-felg-IP2795-Ab-2; GM-Tg-cang-IP2795-Ab-1/ GM-Tg-cang-IP2795-Ab-2; GM-Tg-bovg-IP2795-Ab-1/ GM-Tg-bovg-IP2795-Ab-2; GM-Tg-equg-IP2795-Ab-1/ GM-Tg-equg-IP2795-Ab-2 |
| Products Name | Anti-UBE2D1 monoclonal antibody |
| Format | mab |
| Target Name | UBE2D1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-UBE2D1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2795-Ag-1 | Recombinant multi-species UB2D1/ UBE2D1/ E2(17)KB1 protein |
| ORF Viral Vector | pGMAP000145 | Human UBE2D1 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000145 | Human UBE2D1 Adenovirus particle |
Target information
| Target ID | GM-IP2795 |
| Target Name | UBE2D1 |
| Gene ID | 7321,216080,361831,701491,608578,101099079,535287,100062598 |
| Gene Symbol and Synonyms | E2(17)KB1,SFT,UBC4/5,UBCH5,UBCH5A,UBE2D1 |
| Uniprot Accession | P51668,D3ZDK2,Q2TA10 |
| Uniprot Entry Name | UB2D1_HUMAN,UB2D1_RAT,UB2D1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000072401 |
| Target Classification | N/A |
The target: UBE2D1, gene name: UBE2D1, also named as E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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