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Anti-SAG monoclonal antibody
Pre-made anti-SAG monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SAG/SAG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2908-Ab-1/ GM-Tg-hg-IP2908-Ab-2 | Anti-Human SAG monoclonal antibody | Human |
| GM-Tg-rg-IP2908-Ab-1/ GM-Tg-rg-IP2908-Ab-2 | Anti-Rat SAG monoclonal antibody | Rat |
| GM-Tg-mg-IP2908-Ab-1/ GM-Tg-mg-IP2908-Ab-2 | Anti-Mouse SAG monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2908-Ab-1/ GM-Tg-cynog-IP2908-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SAG monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2908-Ab-1/ GM-Tg-felg-IP2908-Ab-2 | Anti-Feline SAG monoclonal antibody | Feline |
| GM-Tg-cang-IP2908-Ab-1/ GM-Tg-cang-IP2908-Ab-2 | Anti-Canine SAG monoclonal antibody | Canine |
| GM-Tg-bovg-IP2908-Ab-1/ GM-Tg-bovg-IP2908-Ab-2 | Anti-Bovine SAG monoclonal antibody | Bovine |
| GM-Tg-equg-IP2908-Ab-1/ GM-Tg-equg-IP2908-Ab-2 | Anti-Equine SAG monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2908-Ab-1/ GM-Tg-hg-IP2908-Ab-2; GM-Tg-rg-IP2908-Ab-1/ GM-Tg-rg-IP2908-Ab-2; GM-Tg-mg-IP2908-Ab-1/ GM-Tg-mg-IP2908-Ab-2; GM-Tg-cynog-IP2908-Ab-1/ GM-Tg-cynog-IP2908-Ab-2; GM-Tg-felg-IP2908-Ab-1/ GM-Tg-felg-IP2908-Ab-2; GM-Tg-cang-IP2908-Ab-1/ GM-Tg-cang-IP2908-Ab-2; GM-Tg-bovg-IP2908-Ab-1/ GM-Tg-bovg-IP2908-Ab-2; GM-Tg-equg-IP2908-Ab-1/ GM-Tg-equg-IP2908-Ab-2 |
| Products Name | Anti-SAG monoclonal antibody |
| Format | mab |
| Target Name | SAG |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SAG monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2908-Ag-1 | Recombinant multi-species ARRS/ SAG/ RP47 protein |
Target information
| Target ID | GM-IP2908 |
| Target Name | SAG |
| Gene ID | 6295,20215,25539,714160,403906,101100991,280922 |
| Gene Symbol and Synonyms | A930001K18Rik,ARR,Arr1,arrestin,Irbp,RP47,RP96,S-AG,SAG,sag1,SAGMR,SANTI |
| Uniprot Accession | P10523,P15887,Q28281,P08168 |
| Uniprot Entry Name | ARRS_HUMAN,ARRS_RAT,ARRS_CANLF,ARRS_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000130561 |
| Target Classification | N/A |
The target: SAG, gene name: SAG, also named as RP47, S-AG. Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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