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Anti-ACV1C/ ACVR1C/ ACVRLK7 monoclonal antibody
Anti-ACV1C/ ACVR1C/ ACVRLK7 antibody for FACS & in-vivo assay
Go to ACVR1C/ACVR1C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0029-Ab-1/ GM-Tg-hg-MP0029-Ab-2 | Anti-Human ACVR1C monoclonal antibody | Human |
| GM-Tg-rg-MP0029-Ab-1/ GM-Tg-rg-MP0029-Ab-2 | Anti-Rat ACVR1C monoclonal antibody | Rat |
| GM-Tg-mg-MP0029-Ab-1/ GM-Tg-mg-MP0029-Ab-2 | Anti-Mouse ACVR1C monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0029-Ab-1/ GM-Tg-cynog-MP0029-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ACVR1C monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0029-Ab-1/ GM-Tg-felg-MP0029-Ab-2 | Anti-Feline ACVR1C monoclonal antibody | Feline |
| GM-Tg-cang-MP0029-Ab-1/ GM-Tg-cang-MP0029-Ab-2 | Anti-Canine ACVR1C monoclonal antibody | Canine |
| GM-Tg-bovg-MP0029-Ab-1/ GM-Tg-bovg-MP0029-Ab-2 | Anti-Bovine ACVR1C monoclonal antibody | Bovine |
| GM-Tg-equg-MP0029-Ab-1/ GM-Tg-equg-MP0029-Ab-2 | Anti-Equine ACVR1C monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0029-Ab-1/ GM-Tg-hg-MP0029-Ab-2; GM-Tg-rg-MP0029-Ab-1/ GM-Tg-rg-MP0029-Ab-2; GM-Tg-mg-MP0029-Ab-1/ GM-Tg-mg-MP0029-Ab-2; GM-Tg-cynog-MP0029-Ab-1/ GM-Tg-cynog-MP0029-Ab-2; GM-Tg-felg-MP0029-Ab-1/ GM-Tg-felg-MP0029-Ab-2; GM-Tg-cang-MP0029-Ab-1/ GM-Tg-cang-MP0029-Ab-2; GM-Tg-bovg-MP0029-Ab-1/ GM-Tg-bovg-MP0029-Ab-2; GM-Tg-equg-MP0029-Ab-1/ GM-Tg-equg-MP0029-Ab-2 |
| Products Name | Anti-ACVR1C monoclonal antibody |
| Format | mab |
| Target Name | ACVR1C |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ACVR1C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ACV1C/ ACVR1C/ ACVRLK7 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0029-Ag-1 | activin A receptor, type IC (ACVR1C) protein |
Target information
| Target ID | GM-MP0029 |
| Target Name | ACVR1C |
| Gene ID | 130399,269275,245921,697826,488361,101091037,536380,100059573 |
| Gene Symbol and Synonyms | ACTR-IC,ACVR1C,ACVRLK7,Alk-7,ALK7,C230097P10,habrec1 |
| Uniprot Accession | Q8NER5,P70539 |
| Uniprot Entry Name | ACV1C_HUMAN,ACV1C_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000123612 |
| Target Classification | N/A |
The target: ACVR1C, gene name: ACVR1C, also named as ACVRLK7, ALK7. ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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