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Anti-CCR6/ BN-1/ C-C CKR-6 monoclonal antibody
Anti-CCR6/ BN-1/ C-C CKR-6 antibody for FACS & in-vivo assay
Go to CCR6/CCR6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0190-Ab-1/ GM-Tg-hg-MP0190-Ab-2 | Anti-Human CCR6 monoclonal antibody | Human |
| GM-Tg-rg-MP0190-Ab-1/ GM-Tg-rg-MP0190-Ab-2 | Anti-Rat CCR6 monoclonal antibody | Rat |
| GM-Tg-mg-MP0190-Ab-1/ GM-Tg-mg-MP0190-Ab-2 | Anti-Mouse CCR6 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0190-Ab-1/ GM-Tg-cynog-MP0190-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCR6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0190-Ab-1/ GM-Tg-felg-MP0190-Ab-2 | Anti-Feline CCR6 monoclonal antibody | Feline |
| GM-Tg-cang-MP0190-Ab-1/ GM-Tg-cang-MP0190-Ab-2 | Anti-Canine CCR6 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0190-Ab-1/ GM-Tg-bovg-MP0190-Ab-2 | Anti-Bovine CCR6 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0190-Ab-1/ GM-Tg-equg-MP0190-Ab-2 | Anti-Equine CCR6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0190-Ab-1/ GM-Tg-hg-MP0190-Ab-2; GM-Tg-rg-MP0190-Ab-1/ GM-Tg-rg-MP0190-Ab-2; GM-Tg-mg-MP0190-Ab-1/ GM-Tg-mg-MP0190-Ab-2; GM-Tg-cynog-MP0190-Ab-1/ GM-Tg-cynog-MP0190-Ab-2; GM-Tg-felg-MP0190-Ab-1/ GM-Tg-felg-MP0190-Ab-2; GM-Tg-cang-MP0190-Ab-1/ GM-Tg-cang-MP0190-Ab-2; GM-Tg-bovg-MP0190-Ab-1/ GM-Tg-bovg-MP0190-Ab-2; GM-Tg-equg-MP0190-Ab-1/ GM-Tg-equg-MP0190-Ab-2 |
| Products Name | Anti-CCR6 monoclonal antibody |
| Format | mab |
| Target Name | CCR6 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCR6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CCR6/ BN-1/ C-C CKR-6 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0190-Ag-1 | chemokine (C-C motif) receptor 6 (CCR6) protein |
| ORF Viral Vector | vGMLP000600 | human CCR6 Lentivirus particle |
| ORF Viral Vector | pGMLP000600 | human CCR6 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005321 | mouse Ccr6 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005321 | mouse Ccr6 Lentivirus particle |
Target information
| Target ID | GM-MP0190 |
| Target Name | CCR6 |
| Gene ID | 1235,12458,308163,574335,484080,101100307,519716,100055159 |
| Gene Symbol and Synonyms | BN-1,C-C CKR-6,CC-CKR-6,CCR-6,CCR6,CD196,CKR-L3,CKRL3,CMKBR6,DCR2,DRY6,GPR29,GPRCY4,KY411,STRL22 |
| Uniprot Accession | P51684 |
| Uniprot Entry Name | CCR6_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000112486 |
| Target Classification | GPCR, Tumor-associated antigen (TAA) |
The target: CCR6, gene name: CCR6, also named as BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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