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Anti-CCRL2/ ACKR5/ CKRX monoclonal antibody
Anti-CCRL2/ ACKR5/ CKRX antibody for FACS & in-vivo assay
Go to CCRL2/CCRL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0191-Ab-1/ GM-Tg-hg-MP0191-Ab-2 | Anti-Human CCRL2 monoclonal antibody | Human |
| GM-Tg-rg-MP0191-Ab-1/ GM-Tg-rg-MP0191-Ab-2 | Anti-Rat CCRL2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0191-Ab-1/ GM-Tg-mg-MP0191-Ab-2 | Anti-Mouse CCRL2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0191-Ab-1/ GM-Tg-cynog-MP0191-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCRL2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0191-Ab-1/ GM-Tg-felg-MP0191-Ab-2 | Anti-Feline CCRL2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0191-Ab-1/ GM-Tg-cang-MP0191-Ab-2 | Anti-Canine CCRL2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0191-Ab-1/ GM-Tg-bovg-MP0191-Ab-2 | Anti-Bovine CCRL2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0191-Ab-1/ GM-Tg-equg-MP0191-Ab-2 | Anti-Equine CCRL2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0191-Ab-1/ GM-Tg-hg-MP0191-Ab-2; GM-Tg-rg-MP0191-Ab-1/ GM-Tg-rg-MP0191-Ab-2; GM-Tg-mg-MP0191-Ab-1/ GM-Tg-mg-MP0191-Ab-2; GM-Tg-cynog-MP0191-Ab-1/ GM-Tg-cynog-MP0191-Ab-2; GM-Tg-felg-MP0191-Ab-1/ GM-Tg-felg-MP0191-Ab-2; GM-Tg-cang-MP0191-Ab-1/ GM-Tg-cang-MP0191-Ab-2; GM-Tg-bovg-MP0191-Ab-1/ GM-Tg-bovg-MP0191-Ab-2; GM-Tg-equg-MP0191-Ab-1/ GM-Tg-equg-MP0191-Ab-2 |
| Products Name | Anti-CCRL2 monoclonal antibody |
| Format | mab |
| Target Name | CCRL2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCRL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CCRL2/ ACKR5/ CKRX VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0191-Ag-1 | chemokine (C-C motif) receptor-like 2 (CCRL2) protein |
Target information
| Target ID | GM-MP0191 |
| Target Name | CCRL2 |
| Gene ID | 9034,54199,316019,713715,484788,101093252,515976,100054419 |
| Gene Symbol and Synonyms | 1810047I05Rik,ACKR5,CCR11,CCRL2,CKRX,Cmkbr1l2,CRAM,CRAM-A,CRAM-B,E01,HCR,L-CCR |
| Uniprot Accession | O00421,Q9XSD7,Q0II78 |
| Uniprot Entry Name | CCRL2_HUMAN,CCRL2_MACMU,CCRL2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000121797 |
| Target Classification | GPCR |
The target: CCRL2, gene name: CCRL2, also named as ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR. This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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