- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-CERS1/ EPM8/ GDF-1 functional antibody
Anti-CERS1/ EPM8/ GDF-1 functional antibody for cell culture, ELISA & in-vivo assay
Go to CERS1/CERS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0078-Ab-1/ GM-Tg-hg-SE0078-Ab-2 | Anti-Human CERS1 monoclonal antibody | Human |
| GM-Tg-rg-SE0078-Ab-1/ GM-Tg-rg-SE0078-Ab-2 | Anti-Rat CERS1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0078-Ab-1/ GM-Tg-mg-SE0078-Ab-2 | Anti-Mouse CERS1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0078-Ab-1/ GM-Tg-cynog-SE0078-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CERS1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0078-Ab-1/ GM-Tg-felg-SE0078-Ab-2 | Anti-Feline CERS1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0078-Ab-1/ GM-Tg-cang-SE0078-Ab-2 | Anti-Canine CERS1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0078-Ab-1/ GM-Tg-bovg-SE0078-Ab-2 | Anti-Bovine CERS1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0078-Ab-1/ GM-Tg-equg-SE0078-Ab-2 | Anti-Equine CERS1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0078-Ab-1/ GM-Tg-hg-SE0078-Ab-2; GM-Tg-rg-SE0078-Ab-1/ GM-Tg-rg-SE0078-Ab-2; GM-Tg-mg-SE0078-Ab-1/ GM-Tg-mg-SE0078-Ab-2; GM-Tg-cynog-SE0078-Ab-1/ GM-Tg-cynog-SE0078-Ab-2; GM-Tg-felg-SE0078-Ab-1/ GM-Tg-felg-SE0078-Ab-2; GM-Tg-cang-SE0078-Ab-1/ GM-Tg-cang-SE0078-Ab-2; GM-Tg-bovg-SE0078-Ab-1/ GM-Tg-bovg-SE0078-Ab-2; GM-Tg-equg-SE0078-Ab-1/ GM-Tg-equg-SE0078-Ab-2 |
| Products Name | Anti-CERS1 monoclonal antibody |
| Format | mab |
| Target Name | CERS1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CERS1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0078-Ag-1 | Recombinant multi-species CERS1/ EPM8/ GDF-1 protein |
| ORF Viral Vector | pGMLPm002519 | mouse Cers1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002519 | mouse Cers1 Lentivirus particle |
Target information
| Target ID | GM-SE0078 |
| Target Name | CERS1 |
| Gene ID | 10715,93898,290658,106994665,101089084,615296,100069594 |
| Gene Symbol and Synonyms | CERS1,EPM8,GDF-1,GDF1,LAG1,LASS1,to,Uog-1,UOG1 |
| Uniprot Accession | P27544 |
| Uniprot Entry Name | CERS1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000223802 |
| Target Classification | N/A |
The target: CERS1, gene name: CERS1, also named as EPM8, GDF-1, GDF1, LAG1, LASS1, UOG1. This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Elevated expression of this gene may be associated with increased longevity, while decreased expression of this gene may be associated with myoclonus epilepsy with dementia in human patients. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
