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Anti-FHR5/ CFHR5/ CFHL5D functional antibody
Anti-FHR5/ CFHR5/ CFHL5D functional antibody for cell culture, ELISA & in-vivo assay
Go to CFHR5/CFHR5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0079-Ab-1/ GM-Tg-hg-SE0079-Ab-2 | Anti-Human CFHR5 monoclonal antibody | Human |
| GM-Tg-rg-SE0079-Ab-1/ GM-Tg-rg-SE0079-Ab-2 | Anti-Rat CFHR5 monoclonal antibody | Rat |
| GM-Tg-mg-SE0079-Ab-1/ GM-Tg-mg-SE0079-Ab-2 | Anti-Mouse CFHR5 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0079-Ab-1/ GM-Tg-cynog-SE0079-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CFHR5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0079-Ab-1/ GM-Tg-felg-SE0079-Ab-2 | Anti-Feline CFHR5 monoclonal antibody | Feline |
| GM-Tg-cang-SE0079-Ab-1/ GM-Tg-cang-SE0079-Ab-2 | Anti-Canine CFHR5 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0079-Ab-1/ GM-Tg-bovg-SE0079-Ab-2 | Anti-Bovine CFHR5 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0079-Ab-1/ GM-Tg-equg-SE0079-Ab-2 | Anti-Equine CFHR5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0079-Ab-1/ GM-Tg-hg-SE0079-Ab-2; GM-Tg-rg-SE0079-Ab-1/ GM-Tg-rg-SE0079-Ab-2; GM-Tg-mg-SE0079-Ab-1/ GM-Tg-mg-SE0079-Ab-2; GM-Tg-cynog-SE0079-Ab-1/ GM-Tg-cynog-SE0079-Ab-2; GM-Tg-felg-SE0079-Ab-1/ GM-Tg-felg-SE0079-Ab-2; GM-Tg-cang-SE0079-Ab-1/ GM-Tg-cang-SE0079-Ab-2; GM-Tg-bovg-SE0079-Ab-1/ GM-Tg-bovg-SE0079-Ab-2; GM-Tg-equg-SE0079-Ab-1/ GM-Tg-equg-SE0079-Ab-2 |
| Products Name | Anti-CFHR5 monoclonal antibody |
| Format | mab |
| Target Name | CFHR5 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CFHR5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0079-Ag-1 | Recombinant multi-species FHR5/ CFHR5/ CFHL5D protein |
Target information
| Target ID | GM-SE0079 |
| Target Name | CFHR5 |
| Gene ID | 81494,106994227,490262,101091337 |
| Gene Symbol and Synonyms | CFHL5,CFHR2,CFHR5,CFHR5D,FHR-5,FHR5 |
| Uniprot Accession | Q9BXR6 |
| Uniprot Entry Name | FHR5_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000134389 |
| Target Classification | N/A |
The target: CFHR5, gene name: CFHR5, also named as CFHL5D, FHR-5, FHR5, CFHR5. This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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