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Anti-CSTN1/ CLSTN1/ ALC-ALPHA functional antibody
Anti-CSTN1/ CLSTN1/ ALC-ALPHA functional antibody for cell culture, ELISA & in-vivo assay
Go to CLSTN1/CLSTN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0098-Ab-1/ GM-Tg-hg-SE0098-Ab-2 | Anti-Human CLSTN1 monoclonal antibody | Human |
| GM-Tg-rg-SE0098-Ab-1/ GM-Tg-rg-SE0098-Ab-2 | Anti-Rat CLSTN1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0098-Ab-1/ GM-Tg-mg-SE0098-Ab-2 | Anti-Mouse CLSTN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0098-Ab-1/ GM-Tg-cynog-SE0098-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLSTN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0098-Ab-1/ GM-Tg-felg-SE0098-Ab-2 | Anti-Feline CLSTN1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0098-Ab-1/ GM-Tg-cang-SE0098-Ab-2 | Anti-Canine CLSTN1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0098-Ab-1/ GM-Tg-bovg-SE0098-Ab-2 | Anti-Bovine CLSTN1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0098-Ab-1/ GM-Tg-equg-SE0098-Ab-2 | Anti-Equine CLSTN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0098-Ab-1/ GM-Tg-hg-SE0098-Ab-2; GM-Tg-rg-SE0098-Ab-1/ GM-Tg-rg-SE0098-Ab-2; GM-Tg-mg-SE0098-Ab-1/ GM-Tg-mg-SE0098-Ab-2; GM-Tg-cynog-SE0098-Ab-1/ GM-Tg-cynog-SE0098-Ab-2; GM-Tg-felg-SE0098-Ab-1/ GM-Tg-felg-SE0098-Ab-2; GM-Tg-cang-SE0098-Ab-1/ GM-Tg-cang-SE0098-Ab-2; GM-Tg-bovg-SE0098-Ab-1/ GM-Tg-bovg-SE0098-Ab-2; GM-Tg-equg-SE0098-Ab-1/ GM-Tg-equg-SE0098-Ab-2 |
| Products Name | Anti-CLSTN1 monoclonal antibody |
| Format | mab |
| Target Name | CLSTN1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLSTN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0098-Ag-1 | Recombinant multi-species CSTN1/ CLSTN1/ ALC-ALPHA protein |
Target information
| Target ID | GM-SE0098 |
| Target Name | CLSTN1 |
| Gene ID | 22883,65945,313717,722304,101098804,514447,100057452 |
| Gene Symbol and Synonyms | 1810034E21Rik,ALC-ALPHA,alcalpha1,alcalpha2,CDHR12,CLSTN1,CST-1,CSTN1,PIK3CD,XB31alpha |
| Uniprot Accession | O94985,Q6Q0N0 |
| Uniprot Entry Name | CSTN1_HUMAN,CSTN1_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000171603 |
| Target Classification | N/A |
The target: CLSTN1, gene name: CLSTN1, also named as ALC-ALPHA, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2. This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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