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Anti-COBA2/ COL11A2/ DFNA13 functional antibody
Anti-COBA2/ COL11A2/ DFNA13 functional antibody for cell culture, ELISA & in-vivo assay
Go to COL11A2/COL11A2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0100-Ab-1/ GM-Tg-hg-SE0100-Ab-2 | Anti-Human COL11A2 monoclonal antibody | Human |
| GM-Tg-rg-SE0100-Ab-1/ GM-Tg-rg-SE0100-Ab-2 | Anti-Rat COL11A2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0100-Ab-1/ GM-Tg-mg-SE0100-Ab-2 | Anti-Mouse COL11A2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0100-Ab-1/ GM-Tg-cynog-SE0100-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COL11A2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0100-Ab-1/ GM-Tg-felg-SE0100-Ab-2 | Anti-Feline COL11A2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0100-Ab-1/ GM-Tg-cang-SE0100-Ab-2 | Anti-Canine COL11A2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0100-Ab-1/ GM-Tg-bovg-SE0100-Ab-2 | Anti-Bovine COL11A2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0100-Ab-1/ GM-Tg-equg-SE0100-Ab-2 | Anti-Equine COL11A2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0100-Ab-1/ GM-Tg-hg-SE0100-Ab-2; GM-Tg-rg-SE0100-Ab-1/ GM-Tg-rg-SE0100-Ab-2; GM-Tg-mg-SE0100-Ab-1/ GM-Tg-mg-SE0100-Ab-2; GM-Tg-cynog-SE0100-Ab-1/ GM-Tg-cynog-SE0100-Ab-2; GM-Tg-felg-SE0100-Ab-1/ GM-Tg-felg-SE0100-Ab-2; GM-Tg-cang-SE0100-Ab-1/ GM-Tg-cang-SE0100-Ab-2; GM-Tg-bovg-SE0100-Ab-1/ GM-Tg-bovg-SE0100-Ab-2; GM-Tg-equg-SE0100-Ab-1/ GM-Tg-equg-SE0100-Ab-2 |
| Products Name | Anti-COL11A2 monoclonal antibody |
| Format | mab |
| Target Name | COL11A2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COL11A2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0100-Ag-1 | Recombinant multi-species COBA2/ COL11A2/ DFNA13 protein |
Target information
| Target ID | GM-SE0100 |
| Target Name | COL11A2 |
| Gene ID | 1302,12815,294279,718050,481734,101085209,515435,100061226 |
| Gene Symbol and Synonyms | COL11A2,DFNA13,DFNB53,FBCG2,HKE5,OSMEDA,OSMEDB,PARP,STL3 |
| Uniprot Accession | P13942,Q32S24 |
| Uniprot Entry Name | COBA2_HUMAN,COBA2_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000204248 |
| Target Classification | N/A |
The target: COL11A2, gene name: COL11A2, also named as DFNA13, DFNB53, FBCG2, HKE5, OSMEDA, OSMEDB, PARP, STL3. This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6. [provided by RefSeq, Jul 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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