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Anti-CO1A1/ COL1A1/ EDSARTH1 functional antibody
Anti-CO1A1/ COL1A1/ EDSARTH1 functional antibody for cell culture, ELISA & in-vivo assay
Go to COL1A1/COL1A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0103-Ab-1/ GM-Tg-hg-SE0103-Ab-2 | Anti-Human COL1A1 monoclonal antibody | Human |
| GM-Tg-rg-SE0103-Ab-1/ GM-Tg-rg-SE0103-Ab-2 | Anti-Rat COL1A1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0103-Ab-1/ GM-Tg-mg-SE0103-Ab-2 | Anti-Mouse COL1A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0103-Ab-1/ GM-Tg-cynog-SE0103-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COL1A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0103-Ab-1/ GM-Tg-felg-SE0103-Ab-2 | Anti-Feline COL1A1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0103-Ab-1/ GM-Tg-cang-SE0103-Ab-2 | Anti-Canine COL1A1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0103-Ab-1/ GM-Tg-bovg-SE0103-Ab-2 | Anti-Bovine COL1A1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0103-Ab-1/ GM-Tg-equg-SE0103-Ab-2 | Anti-Equine COL1A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0103-Ab-1/ GM-Tg-hg-SE0103-Ab-2; GM-Tg-rg-SE0103-Ab-1/ GM-Tg-rg-SE0103-Ab-2; GM-Tg-mg-SE0103-Ab-1/ GM-Tg-mg-SE0103-Ab-2; GM-Tg-cynog-SE0103-Ab-1/ GM-Tg-cynog-SE0103-Ab-2; GM-Tg-felg-SE0103-Ab-1/ GM-Tg-felg-SE0103-Ab-2; GM-Tg-cang-SE0103-Ab-1/ GM-Tg-cang-SE0103-Ab-2; GM-Tg-bovg-SE0103-Ab-1/ GM-Tg-bovg-SE0103-Ab-2; GM-Tg-equg-SE0103-Ab-1/ GM-Tg-equg-SE0103-Ab-2 |
| Products Name | Anti-COL1A1 monoclonal antibody |
| Format | mab |
| Target Name | COL1A1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COL1A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0103-Ag-1 | Recombinant multi-species CO1A1/ COL1A1/ EDSARTH1 protein |
Target information
| Target ID | GM-SE0103 |
| Target Name | COL1A1 |
| Gene ID | 1277,12842,29393,574201,403651,101092216,282187,100033877 |
| Gene Symbol and Synonyms | CAFYD,Col1a-1,COL1A1,Cola-1,Cola1,COLIA1,EDSARTH1,EDSC,Mov-13,Mov13,OI1,OI2,OI3,OI4 |
| Uniprot Accession | P02452,P02454,Q9XSJ7,P02453 |
| Uniprot Entry Name | CO1A1_HUMAN,CO1A1_RAT,CO1A1_CANLF,CO1A1_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Osteoporosis |
| Gene Ensembl | ENSG00000108821 |
| Target Classification | N/A |
The target: COL1A1, gene name: COL1A1, also named as EDSARTH1, EDSC, OI1, OI2, OI3, OI4. This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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