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Anti-CO2A1/ COL2A1/ ANFH functional antibody
Anti-CO2A1/ COL2A1/ ANFH functional antibody for cell culture, ELISA & in-vivo assay
Go to COL2A1/COL2A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0105-Ab-1/ GM-Tg-hg-SE0105-Ab-2 | Anti-Human COL2A1 monoclonal antibody | Human |
| GM-Tg-rg-SE0105-Ab-1/ GM-Tg-rg-SE0105-Ab-2 | Anti-Rat COL2A1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0105-Ab-1/ GM-Tg-mg-SE0105-Ab-2 | Anti-Mouse COL2A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0105-Ab-1/ GM-Tg-cynog-SE0105-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COL2A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0105-Ab-1/ GM-Tg-felg-SE0105-Ab-2 | Anti-Feline COL2A1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0105-Ab-1/ GM-Tg-cang-SE0105-Ab-2 | Anti-Canine COL2A1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0105-Ab-1/ GM-Tg-bovg-SE0105-Ab-2 | Anti-Bovine COL2A1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0105-Ab-1/ GM-Tg-equg-SE0105-Ab-2 | Anti-Equine COL2A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0105-Ab-1/ GM-Tg-hg-SE0105-Ab-2; GM-Tg-rg-SE0105-Ab-1/ GM-Tg-rg-SE0105-Ab-2; GM-Tg-mg-SE0105-Ab-1/ GM-Tg-mg-SE0105-Ab-2; GM-Tg-cynog-SE0105-Ab-1/ GM-Tg-cynog-SE0105-Ab-2; GM-Tg-felg-SE0105-Ab-1/ GM-Tg-felg-SE0105-Ab-2; GM-Tg-cang-SE0105-Ab-1/ GM-Tg-cang-SE0105-Ab-2; GM-Tg-bovg-SE0105-Ab-1/ GM-Tg-bovg-SE0105-Ab-2; GM-Tg-equg-SE0105-Ab-1/ GM-Tg-equg-SE0105-Ab-2 |
| Products Name | Anti-COL2A1 monoclonal antibody |
| Format | mab |
| Target Name | COL2A1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COL2A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0105-Ag-1 | Recombinant multi-species CO2A1/ COL2A1/ ANFH protein |
Target information
| Target ID | GM-SE0105 |
| Target Name | COL2A1 |
| Gene ID | 1280,12824,25412,704851,403826,101087493,407142,791241 |
| Gene Symbol and Synonyms | ANFH,AOM,CB11,CG2A1A,COL11A3,Col2,Col2a,Col2a-1,COL2A1,COLLII,Del1,Dmm,Lpk,M100413,Rgsc413,Rgsc856,SEDC,STL1 |
| Uniprot Accession | P02458,P05539,P02459 |
| Uniprot Entry Name | CO2A1_HUMAN,CO2A1_RAT,CO2A1_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Rheumatoid vasculitis with rheumatoid arthritis, Osteoarthritis |
| Gene Ensembl | ENSG00000139219 |
| Target Classification | N/A |
The target: COL2A1, gene name: COL2A1, also named as ANFH, AOM, COL11A3, SEDC, STL1. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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