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Anti-CO5A1/ COL5A1/ EDSC functional antibody
Anti-CO5A1/ COL5A1/ EDSC functional antibody for cell culture, ELISA & in-vivo assay
Go to COL5A1/COL5A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0108-Ab-1/ GM-Tg-hg-SE0108-Ab-2 | Anti-Human COL5A1 monoclonal antibody | Human |
| GM-Tg-rg-SE0108-Ab-1/ GM-Tg-rg-SE0108-Ab-2 | Anti-Rat COL5A1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0108-Ab-1/ GM-Tg-mg-SE0108-Ab-2 | Anti-Mouse COL5A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0108-Ab-1/ GM-Tg-cynog-SE0108-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COL5A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0108-Ab-1/ GM-Tg-felg-SE0108-Ab-2 | Anti-Feline COL5A1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0108-Ab-1/ GM-Tg-cang-SE0108-Ab-2 | Anti-Canine COL5A1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0108-Ab-1/ GM-Tg-bovg-SE0108-Ab-2 | Anti-Bovine COL5A1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0108-Ab-1/ GM-Tg-equg-SE0108-Ab-2 | Anti-Equine COL5A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0108-Ab-1/ GM-Tg-hg-SE0108-Ab-2; GM-Tg-rg-SE0108-Ab-1/ GM-Tg-rg-SE0108-Ab-2; GM-Tg-mg-SE0108-Ab-1/ GM-Tg-mg-SE0108-Ab-2; GM-Tg-cynog-SE0108-Ab-1/ GM-Tg-cynog-SE0108-Ab-2; GM-Tg-felg-SE0108-Ab-1/ GM-Tg-felg-SE0108-Ab-2; GM-Tg-cang-SE0108-Ab-1/ GM-Tg-cang-SE0108-Ab-2; GM-Tg-bovg-SE0108-Ab-1/ GM-Tg-bovg-SE0108-Ab-2; GM-Tg-equg-SE0108-Ab-1/ GM-Tg-equg-SE0108-Ab-2 |
| Products Name | Anti-COL5A1 monoclonal antibody |
| Format | mab |
| Target Name | COL5A1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COL5A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0108-Ag-1 | Recombinant multi-species CO5A1/ COL5A1/ EDSC protein |
Target information
| Target ID | GM-SE0108 |
| Target Name | COL5A1 |
| Gene ID | 1289,12831,85490,722014,480684,101082193,100848491,100069057 |
| Gene Symbol and Synonyms | COL5A1,EDSC,EDSCL1,FMDMF |
| Uniprot Accession | P20908,Q9JI03 |
| Uniprot Entry Name | CO5A1_HUMAN,CO5A1_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000130635 |
| Target Classification | N/A |
The target: COL5A1, gene name: COL5A1, also named as EDSC, EDSCL1. This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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