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Anti-CO6A1/ COL6A1/ BTHLM1 functional antibody
Anti-CO6A1/ COL6A1/ BTHLM1 functional antibody for cell culture, ELISA & in-vivo assay
Go to COL6A1/COL6A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0111-Ab-1/ GM-Tg-hg-SE0111-Ab-2 | Anti-Human COL6A1 monoclonal antibody | Human |
| GM-Tg-rg-SE0111-Ab-1/ GM-Tg-rg-SE0111-Ab-2 | Anti-Rat COL6A1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0111-Ab-1/ GM-Tg-mg-SE0111-Ab-2 | Anti-Mouse COL6A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0111-Ab-1/ GM-Tg-cynog-SE0111-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COL6A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0111-Ab-1/ GM-Tg-felg-SE0111-Ab-2 | Anti-Feline COL6A1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0111-Ab-1/ GM-Tg-cang-SE0111-Ab-2 | Anti-Canine COL6A1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0111-Ab-1/ GM-Tg-bovg-SE0111-Ab-2 | Anti-Bovine COL6A1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0111-Ab-1/ GM-Tg-equg-SE0111-Ab-2 | Anti-Equine COL6A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0111-Ab-1/ GM-Tg-hg-SE0111-Ab-2; GM-Tg-rg-SE0111-Ab-1/ GM-Tg-rg-SE0111-Ab-2; GM-Tg-mg-SE0111-Ab-1/ GM-Tg-mg-SE0111-Ab-2; GM-Tg-cynog-SE0111-Ab-1/ GM-Tg-cynog-SE0111-Ab-2; GM-Tg-felg-SE0111-Ab-1/ GM-Tg-felg-SE0111-Ab-2; GM-Tg-cang-SE0111-Ab-1/ GM-Tg-cang-SE0111-Ab-2; GM-Tg-bovg-SE0111-Ab-1/ GM-Tg-bovg-SE0111-Ab-2; GM-Tg-equg-SE0111-Ab-1/ GM-Tg-equg-SE0111-Ab-2 |
| Products Name | Anti-COL6A1 monoclonal antibody |
| Format | mab |
| Target Name | COL6A1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COL6A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0111-Ag-1 | Recombinant multi-species CO6A1/ COL6A1/ BTHLM1 protein |
Target information
| Target ID | GM-SE0111 |
| Target Name | COL6A1 |
| Gene ID | 1291,12833,294337,721855,403668,101081156,511422,100050035 |
| Gene Symbol and Synonyms | BTHLM1,Col6a-1,COL6A1,OPLL,RGD1565398,UCHMD1 |
| Uniprot Accession | P12109 |
| Uniprot Entry Name | CO6A1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000142156 |
| Target Classification | N/A |
The target: COL6A1, gene name: COL6A1, also named as BTHLM1, OPLL, UCHMD1. The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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