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Anti-CST11/ CST8L/ CTES2 functional antibody
Anti-CST11/ CST8L/ CTES2 functional antibody for cell culture, ELISA & in-vivo assay
Go to CST11/CST11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0128-Ab-1/ GM-Tg-hg-SE0128-Ab-2 | Anti-Human CST11 monoclonal antibody | Human |
| GM-Tg-rg-SE0128-Ab-1/ GM-Tg-rg-SE0128-Ab-2 | Anti-Rat CST11 monoclonal antibody | Rat |
| GM-Tg-mg-SE0128-Ab-1/ GM-Tg-mg-SE0128-Ab-2 | Anti-Mouse CST11 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0128-Ab-1/ GM-Tg-cynog-SE0128-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CST11 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0128-Ab-1/ GM-Tg-felg-SE0128-Ab-2 | Anti-Feline CST11 monoclonal antibody | Feline |
| GM-Tg-cang-SE0128-Ab-1/ GM-Tg-cang-SE0128-Ab-2 | Anti-Canine CST11 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0128-Ab-1/ GM-Tg-bovg-SE0128-Ab-2 | Anti-Bovine CST11 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0128-Ab-1/ GM-Tg-equg-SE0128-Ab-2 | Anti-Equine CST11 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0128-Ab-1/ GM-Tg-hg-SE0128-Ab-2; GM-Tg-rg-SE0128-Ab-1/ GM-Tg-rg-SE0128-Ab-2; GM-Tg-mg-SE0128-Ab-1/ GM-Tg-mg-SE0128-Ab-2; GM-Tg-cynog-SE0128-Ab-1/ GM-Tg-cynog-SE0128-Ab-2; GM-Tg-felg-SE0128-Ab-1/ GM-Tg-felg-SE0128-Ab-2; GM-Tg-cang-SE0128-Ab-1/ GM-Tg-cang-SE0128-Ab-2; GM-Tg-bovg-SE0128-Ab-1/ GM-Tg-bovg-SE0128-Ab-2; GM-Tg-equg-SE0128-Ab-1/ GM-Tg-equg-SE0128-Ab-2 |
| Products Name | Anti-CST11 monoclonal antibody |
| Format | mab |
| Target Name | CST11 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CST11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0128-Ag-1 | Recombinant multi-species CST11/ CST8L/ CTES2 protein |
Target information
| Target ID | GM-SE0128 |
| Target Name | CST11 |
| Gene ID | 140880,78240,245916,654419,606832,101087570,523144,100058925 |
| Gene Symbol and Synonyms | 9230101F08Rik,CRES2,CST11,CST8L,CTES2,dJ322G13.6,ESP16.5,mCSTE1,SC13 |
| Uniprot Accession | Q9H112,Q8K5A3 |
| Uniprot Entry Name | CST11_HUMAN,CST11_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000125831 |
| Target Classification | N/A |
The target: CST11, gene name: CST11, also named as CST8L, CTES2, SC13, dJ322G13.6. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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