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Anti-CTRB1/ CTRB functional antibody
Anti-CTRB1/ CTRB functional antibody for cell culture, ELISA & in-vivo assay
Go to CTRB1/CTRB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0132-Ab-1/ GM-Tg-hg-SE0132-Ab-2 | Anti-Human CTRB1 monoclonal antibody | Human |
| GM-Tg-rg-SE0132-Ab-1/ GM-Tg-rg-SE0132-Ab-2 | Anti-Rat CTRB1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0132-Ab-1/ GM-Tg-mg-SE0132-Ab-2 | Anti-Mouse CTRB1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0132-Ab-1/ GM-Tg-cynog-SE0132-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CTRB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0132-Ab-1/ GM-Tg-felg-SE0132-Ab-2 | Anti-Feline CTRB1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0132-Ab-1/ GM-Tg-cang-SE0132-Ab-2 | Anti-Canine CTRB1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0132-Ab-1/ GM-Tg-bovg-SE0132-Ab-2 | Anti-Bovine CTRB1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0132-Ab-1/ GM-Tg-equg-SE0132-Ab-2 | Anti-Equine CTRB1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0132-Ab-1/ GM-Tg-hg-SE0132-Ab-2; GM-Tg-rg-SE0132-Ab-1/ GM-Tg-rg-SE0132-Ab-2; GM-Tg-mg-SE0132-Ab-1/ GM-Tg-mg-SE0132-Ab-2; GM-Tg-cynog-SE0132-Ab-1/ GM-Tg-cynog-SE0132-Ab-2; GM-Tg-felg-SE0132-Ab-1/ GM-Tg-felg-SE0132-Ab-2; GM-Tg-cang-SE0132-Ab-1/ GM-Tg-cang-SE0132-Ab-2; GM-Tg-bovg-SE0132-Ab-1/ GM-Tg-bovg-SE0132-Ab-2; GM-Tg-equg-SE0132-Ab-1/ GM-Tg-equg-SE0132-Ab-2 |
| Products Name | Anti-CTRB1 monoclonal antibody |
| Format | mab |
| Target Name | CTRB1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CTRB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0132-Ag-1 | Recombinant multi-species CTRB1/ CTRB protein |
Target information
| Target ID | GM-SE0132 |
| Target Name | CTRB1 |
| Gene ID | 1504,618826 |
| Gene Symbol and Synonyms | CTRB,CTRB1,LOC618826 |
| Uniprot Accession | P17538 |
| Uniprot Entry Name | CTRB1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000168925 |
| Target Classification | N/A |
The target: CTRB1, gene name: CTRB1, also named as CTRB. This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This CTRB1 gene is located head-to-head with the related CTRB2 gene. Some human populations have an alternate haplotype which inverts a 16.6 Kb region containing portions of intron 1, exon 1, and the upstream sequence of the CTRB1 and CTRB2 genes. In this inversion haplotype exon 1 and flanking sequence is swapped in CTRB1 and CTRB2. This inversion is associated with differential gene expression and increased risk for chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 of the CTRB1 gene. SNP rs8048956 in intron 1 of the CTRB2 gene is diagnostic for this inversion. This CTRB1 gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jan 2021].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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