Anti-CP2E1/ CYP2E1/ CPE1 functional antibody

Anti-CP2E1/ CYP2E1/ CPE1 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CYP2E1/CYP2E1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0139-Ab-1/ GM-Tg-hg-SE0139-Ab-2Anti-Human CYP2E1 monoclonal antibodyHuman
GM-Tg-rg-SE0139-Ab-1/ GM-Tg-rg-SE0139-Ab-2Anti-Rat CYP2E1 monoclonal antibodyRat
GM-Tg-mg-SE0139-Ab-1/ GM-Tg-mg-SE0139-Ab-2Anti-Mouse CYP2E1 monoclonal antibodyMouse
GM-Tg-cynog-SE0139-Ab-1/ GM-Tg-cynog-SE0139-Ab-2Anti-Cynomolgus/ Rhesus macaque CYP2E1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0139-Ab-1/ GM-Tg-felg-SE0139-Ab-2Anti-Feline CYP2E1 monoclonal antibodyFeline
GM-Tg-cang-SE0139-Ab-1/ GM-Tg-cang-SE0139-Ab-2Anti-Canine CYP2E1 monoclonal antibodyCanine
GM-Tg-bovg-SE0139-Ab-1/ GM-Tg-bovg-SE0139-Ab-2Anti-Bovine CYP2E1 monoclonal antibodyBovine
GM-Tg-equg-SE0139-Ab-1/ GM-Tg-equg-SE0139-Ab-2Anti-Equine CYP2E1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0139-Ab-1/ GM-Tg-hg-SE0139-Ab-2; GM-Tg-rg-SE0139-Ab-1/ GM-Tg-rg-SE0139-Ab-2;
GM-Tg-mg-SE0139-Ab-1/ GM-Tg-mg-SE0139-Ab-2; GM-Tg-cynog-SE0139-Ab-1/ GM-Tg-cynog-SE0139-Ab-2;
GM-Tg-felg-SE0139-Ab-1/ GM-Tg-felg-SE0139-Ab-2; GM-Tg-cang-SE0139-Ab-1/ GM-Tg-cang-SE0139-Ab-2;
GM-Tg-bovg-SE0139-Ab-1/ GM-Tg-bovg-SE0139-Ab-2; GM-Tg-equg-SE0139-Ab-1/ GM-Tg-equg-SE0139-Ab-2
Products NameAnti-CYP2E1 monoclonal antibody
Formatmab
Target NameCYP2E1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CYP2E1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0139-Ag-1Recombinant multi-species CP2E1/ CYP2E1/ CPE1 protein
    ORF Viral VectorvGMLP003765human CYP2E1 Lentivirus particle
    ORF Viral VectorpGMLP003765human CYP2E1 Lentivirus plasmid
    ORF Viral VectorpGMAD000351rat Cyp2e1 Adenovirus plasmid
    ORF Viral VectorpGMAD000352rat Cyp2e1 Adenovirus plasmid
    ORF Viral VectorpGMAD000473Norway rat Cyp2e1 Adenovirus plasmid
    ORF Viral VectorpGMLPm001538mouse Cyp2e1 Lentivirus plasmid
    ORF Viral VectorvGMAD000351rat Cyp2e1 Adenovirus particle
    ORF Viral VectorvGMAD000352rat Cyp2e1 Adenovirus particle
    ORF Viral VectorvGMAD000473Norway rat Cyp2e1 Adenovirus particle
    ORF Viral VectorvGMLPm001538mouse Cyp2e1 Lentivirus particle


    Target information

    Target IDGM-SE0139
    Target NameCYP2E1
    Gene ID1571,13106,25086,415128,554227,282213,100066422
    Gene Symbol and SynonymsCPE1,CYP2E,CYP2E1,CYP2E2,CYPIIE1,P450-J,P450C2E
    Uniprot AccessionP05181,P05182,Q9MZY0,O18963
    Uniprot Entry NameCP2E1_HUMAN,CP2E1_RAT,CP2E1_CANLF,CP2E1_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseCancer
    Gene EnsemblENSG00000130649
    Target ClassificationTumor-associated antigen (TAA)

    The target: CYP2E1, gene name: CYP2E1, also named as CPE1, CYP2E, P450-J, P450C2E. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.