- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-DHRS9/ 3-alpha-HSD/ 3ALPHA-HSD functional antibody
Anti-DHRS9/ 3-alpha-HSD/ 3ALPHA-HSD functional antibody for cell culture, ELISA & in-vivo assay
Go to DHRS9/DHRS9 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0156-Ab-1/ GM-Tg-hg-SE0156-Ab-2 | Anti-Human DHRS9 monoclonal antibody | Human |
| GM-Tg-rg-SE0156-Ab-1/ GM-Tg-rg-SE0156-Ab-2 | Anti-Rat DHRS9 monoclonal antibody | Rat |
| GM-Tg-mg-SE0156-Ab-1/ GM-Tg-mg-SE0156-Ab-2 | Anti-Mouse DHRS9 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0156-Ab-1/ GM-Tg-cynog-SE0156-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DHRS9 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0156-Ab-1/ GM-Tg-felg-SE0156-Ab-2 | Anti-Feline DHRS9 monoclonal antibody | Feline |
| GM-Tg-cang-SE0156-Ab-1/ GM-Tg-cang-SE0156-Ab-2 | Anti-Canine DHRS9 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0156-Ab-1/ GM-Tg-bovg-SE0156-Ab-2 | Anti-Bovine DHRS9 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0156-Ab-1/ GM-Tg-equg-SE0156-Ab-2 | Anti-Equine DHRS9 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0156-Ab-1/ GM-Tg-hg-SE0156-Ab-2; GM-Tg-rg-SE0156-Ab-1/ GM-Tg-rg-SE0156-Ab-2; GM-Tg-mg-SE0156-Ab-1/ GM-Tg-mg-SE0156-Ab-2; GM-Tg-cynog-SE0156-Ab-1/ GM-Tg-cynog-SE0156-Ab-2; GM-Tg-felg-SE0156-Ab-1/ GM-Tg-felg-SE0156-Ab-2; GM-Tg-cang-SE0156-Ab-1/ GM-Tg-cang-SE0156-Ab-2; GM-Tg-bovg-SE0156-Ab-1/ GM-Tg-bovg-SE0156-Ab-2; GM-Tg-equg-SE0156-Ab-1/ GM-Tg-equg-SE0156-Ab-2 |
| Products Name | Anti-DHRS9 monoclonal antibody |
| Format | mab |
| Target Name | DHRS9 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DHRS9 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0156-Ag-1 | Recombinant multi-species DHRS9/ 3-alpha-HSD/ 3ALPHA-HSD protein |
| ORF Viral Vector | pGMLP002443 | human DHRS9 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002443 | human DHRS9 Lentivirus particle |
| ORF Viral Vector | pGMLPm000740 | mouse Dhrs9 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000740 | mouse Dhrs9 Lentivirus particle |
Target information
| Target ID | GM-SE0156 |
| Target Name | DHRS9 |
| Gene ID | 10170,241452,170635,705554,488391,101085993,282851,100052420 |
| Gene Symbol and Synonyms | 3-alpha-HSD,3ALPHA-HSD,C730025I08Rik,DHRS9,hRoDH-E2,RDH-TBE,RDH15,RDHL,RDHTBE,RETSDR8,SDR9C4 |
| Uniprot Accession | Q9BPW9,Q8VD48,Q8HYR6 |
| Uniprot Entry Name | DHRS9_HUMAN,DHRS9_RAT,DHRS9_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000073737 |
| Target Classification | N/A |
The target: DHRS9, gene name: DHRS9, also named as 3-alpha-HSD, 3ALPHA-HSD, RDH-E2, RDH-TBE, RDH15, RDHL, RDHTBE, RETSDR8, SDR9C4. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
