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Anti-ECM1/ URBWD functional antibody
Anti-ECM1/ URBWD functional antibody for cell culture, ELISA & in-vivo assay
Go to ECM1/ECM1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0164-Ab-1/ GM-Tg-hg-SE0164-Ab-2 | Anti-Human ECM1 monoclonal antibody | Human |
| GM-Tg-rg-SE0164-Ab-1/ GM-Tg-rg-SE0164-Ab-2 | Anti-Rat ECM1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0164-Ab-1/ GM-Tg-mg-SE0164-Ab-2 | Anti-Mouse ECM1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0164-Ab-1/ GM-Tg-cynog-SE0164-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ECM1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0164-Ab-1/ GM-Tg-felg-SE0164-Ab-2 | Anti-Feline ECM1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0164-Ab-1/ GM-Tg-cang-SE0164-Ab-2 | Anti-Canine ECM1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0164-Ab-1/ GM-Tg-bovg-SE0164-Ab-2 | Anti-Bovine ECM1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0164-Ab-1/ GM-Tg-equg-SE0164-Ab-2 | Anti-Equine ECM1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0164-Ab-1/ GM-Tg-hg-SE0164-Ab-2; GM-Tg-rg-SE0164-Ab-1/ GM-Tg-rg-SE0164-Ab-2; GM-Tg-mg-SE0164-Ab-1/ GM-Tg-mg-SE0164-Ab-2; GM-Tg-cynog-SE0164-Ab-1/ GM-Tg-cynog-SE0164-Ab-2; GM-Tg-felg-SE0164-Ab-1/ GM-Tg-felg-SE0164-Ab-2; GM-Tg-cang-SE0164-Ab-1/ GM-Tg-cang-SE0164-Ab-2; GM-Tg-bovg-SE0164-Ab-1/ GM-Tg-bovg-SE0164-Ab-2; GM-Tg-equg-SE0164-Ab-1/ GM-Tg-equg-SE0164-Ab-2 |
| Products Name | Anti-ECM1 monoclonal antibody |
| Format | mab |
| Target Name | ECM1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ECM1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0164-Ag-1 | Recombinant multi-species ECM1/ URBWD protein |
| ORF Viral Vector | pGMLPm004954 | mouse Ecm1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004955 | mouse Ecm1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004954 | mouse Ecm1 Lentivirus particle |
| ORF Viral Vector | vGMLPm004955 | mouse Ecm1 Lentivirus particle |
Target information
| Target ID | GM-SE0164 |
| Target Name | ECM1 |
| Gene ID | 1893,13601,116662,707209,608791,101089706,524222,100054714 |
| Gene Symbol and Synonyms | ECM1,p85,URBWD |
| Uniprot Accession | Q16610,Q62894 |
| Uniprot Entry Name | ECM1_HUMAN,ECM1_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000143369 |
| Target Classification | N/A |
The target: ECM1, gene name: ECM1, also named as URBWD. This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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