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Anti-EP3B/ EDDM3B/ FAM12B functional antibody
Anti-EP3B/ EDDM3B/ FAM12B functional antibody for cell culture, ELISA & in-vivo assay
Go to EDDM3B/EDDM3B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0166-Ab-1/ GM-Tg-hg-SE0166-Ab-2 | Anti-Human EDDM3B monoclonal antibody | Human |
| GM-Tg-rg-SE0166-Ab-1/ GM-Tg-rg-SE0166-Ab-2 | Anti-Rat EDDM3B monoclonal antibody | Rat |
| GM-Tg-mg-SE0166-Ab-1/ GM-Tg-mg-SE0166-Ab-2 | Anti-Mouse EDDM3B monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0166-Ab-1/ GM-Tg-cynog-SE0166-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EDDM3B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0166-Ab-1/ GM-Tg-felg-SE0166-Ab-2 | Anti-Feline EDDM3B monoclonal antibody | Feline |
| GM-Tg-cang-SE0166-Ab-1/ GM-Tg-cang-SE0166-Ab-2 | Anti-Canine EDDM3B monoclonal antibody | Canine |
| GM-Tg-bovg-SE0166-Ab-1/ GM-Tg-bovg-SE0166-Ab-2 | Anti-Bovine EDDM3B monoclonal antibody | Bovine |
| GM-Tg-equg-SE0166-Ab-1/ GM-Tg-equg-SE0166-Ab-2 | Anti-Equine EDDM3B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0166-Ab-1/ GM-Tg-hg-SE0166-Ab-2; GM-Tg-rg-SE0166-Ab-1/ GM-Tg-rg-SE0166-Ab-2; GM-Tg-mg-SE0166-Ab-1/ GM-Tg-mg-SE0166-Ab-2; GM-Tg-cynog-SE0166-Ab-1/ GM-Tg-cynog-SE0166-Ab-2; GM-Tg-felg-SE0166-Ab-1/ GM-Tg-felg-SE0166-Ab-2; GM-Tg-cang-SE0166-Ab-1/ GM-Tg-cang-SE0166-Ab-2; GM-Tg-bovg-SE0166-Ab-1/ GM-Tg-bovg-SE0166-Ab-2; GM-Tg-equg-SE0166-Ab-1/ GM-Tg-equg-SE0166-Ab-2 |
| Products Name | Anti-EDDM3B monoclonal antibody |
| Format | mab |
| Target Name | EDDM3B |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EDDM3B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0166-Ag-1 | Recombinant multi-species EP3B/ EDDM3B/ FAM12B protein |
Target information
| Target ID | GM-SE0166 |
| Target Name | EDDM3B |
| Gene ID | 64184,219026,704471,100687627,101091947,100629968 |
| Gene Symbol and Synonyms | EDDM3B,EP3B,Fam12,FAM12B,Gm75,HE3-BETA,HE3B,RAM1,RAM2 |
| Uniprot Accession | P56851 |
| Uniprot Entry Name | EP3B_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000181552 |
| Target Classification | N/A |
The target: EDDM3B, gene name: EDDM3B, also named as EP3B, FAM12B, HE3-BETA, HE3B, RAM2. Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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