Anti-EDEM3/ C1orf22 functional antibody

Anti-EDEM3/ C1orf22 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to EDEM3/EDEM3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0167-Ab-1/ GM-Tg-hg-SE0167-Ab-2Anti-Human EDEM3 monoclonal antibodyHuman
GM-Tg-rg-SE0167-Ab-1/ GM-Tg-rg-SE0167-Ab-2Anti-Rat EDEM3 monoclonal antibodyRat
GM-Tg-mg-SE0167-Ab-1/ GM-Tg-mg-SE0167-Ab-2Anti-Mouse EDEM3 monoclonal antibodyMouse
GM-Tg-cynog-SE0167-Ab-1/ GM-Tg-cynog-SE0167-Ab-2Anti-Cynomolgus/ Rhesus macaque EDEM3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0167-Ab-1/ GM-Tg-felg-SE0167-Ab-2Anti-Feline EDEM3 monoclonal antibodyFeline
GM-Tg-cang-SE0167-Ab-1/ GM-Tg-cang-SE0167-Ab-2Anti-Canine EDEM3 monoclonal antibodyCanine
GM-Tg-bovg-SE0167-Ab-1/ GM-Tg-bovg-SE0167-Ab-2Anti-Bovine EDEM3 monoclonal antibodyBovine
GM-Tg-equg-SE0167-Ab-1/ GM-Tg-equg-SE0167-Ab-2Anti-Equine EDEM3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0167-Ab-1/ GM-Tg-hg-SE0167-Ab-2; GM-Tg-rg-SE0167-Ab-1/ GM-Tg-rg-SE0167-Ab-2;
GM-Tg-mg-SE0167-Ab-1/ GM-Tg-mg-SE0167-Ab-2; GM-Tg-cynog-SE0167-Ab-1/ GM-Tg-cynog-SE0167-Ab-2;
GM-Tg-felg-SE0167-Ab-1/ GM-Tg-felg-SE0167-Ab-2; GM-Tg-cang-SE0167-Ab-1/ GM-Tg-cang-SE0167-Ab-2;
GM-Tg-bovg-SE0167-Ab-1/ GM-Tg-bovg-SE0167-Ab-2; GM-Tg-equg-SE0167-Ab-1/ GM-Tg-equg-SE0167-Ab-2
Products NameAnti-EDEM3 monoclonal antibody
Formatmab
Target NameEDEM3
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-EDEM3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0167-Ag-1Recombinant multi-species EDEM3/ C1orf22 protein


    Target information

    Target IDGM-SE0167
    Target NameEDEM3
    Gene ID80267,66967,289085,714475,480040,101087192,519058,100052092
    Gene Symbol and Synonyms2310050N11Rik,C1orf22,CDG2V,EDEM3,RGD1561496
    Uniprot AccessionQ9BZQ6
    Uniprot Entry NameEDEM3_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000116406
    Target ClassificationN/A

    The target: EDEM3, gene name: EDEM3, also named as C1orf22. Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.