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Anti-ELN/ ADCL1/ SVAS functional antibody
Anti-ELN/ ADCL1/ SVAS functional antibody for cell culture, ELISA & in-vivo assay
Go to ELN/ELN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0172-Ab-1/ GM-Tg-hg-SE0172-Ab-2 | Anti-Human ELN monoclonal antibody | Human |
| GM-Tg-rg-SE0172-Ab-1/ GM-Tg-rg-SE0172-Ab-2 | Anti-Rat ELN monoclonal antibody | Rat |
| GM-Tg-mg-SE0172-Ab-1/ GM-Tg-mg-SE0172-Ab-2 | Anti-Mouse ELN monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0172-Ab-1/ GM-Tg-cynog-SE0172-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ELN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0172-Ab-1/ GM-Tg-felg-SE0172-Ab-2 | Anti-Feline ELN monoclonal antibody | Feline |
| GM-Tg-cang-SE0172-Ab-1/ GM-Tg-cang-SE0172-Ab-2 | Anti-Canine ELN monoclonal antibody | Canine |
| GM-Tg-bovg-SE0172-Ab-1/ GM-Tg-bovg-SE0172-Ab-2 | Anti-Bovine ELN monoclonal antibody | Bovine |
| GM-Tg-equg-SE0172-Ab-1/ GM-Tg-equg-SE0172-Ab-2 | Anti-Equine ELN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0172-Ab-1/ GM-Tg-hg-SE0172-Ab-2; GM-Tg-rg-SE0172-Ab-1/ GM-Tg-rg-SE0172-Ab-2; GM-Tg-mg-SE0172-Ab-1/ GM-Tg-mg-SE0172-Ab-2; GM-Tg-cynog-SE0172-Ab-1/ GM-Tg-cynog-SE0172-Ab-2; GM-Tg-felg-SE0172-Ab-1/ GM-Tg-felg-SE0172-Ab-2; GM-Tg-cang-SE0172-Ab-1/ GM-Tg-cang-SE0172-Ab-2; GM-Tg-bovg-SE0172-Ab-1/ GM-Tg-bovg-SE0172-Ab-2; GM-Tg-equg-SE0172-Ab-1/ GM-Tg-equg-SE0172-Ab-2 |
| Products Name | Anti-ELN monoclonal antibody |
| Format | mab |
| Target Name | ELN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ELN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0172-Ag-1 | Recombinant multi-species ELN/ ADCL1/ SVAS protein |
Target information
| Target ID | GM-SE0172 |
| Target Name | ELN |
| Gene ID | 2006,13717,25043,574132,607775,101093909,280781,102150882 |
| Gene Symbol and Synonyms | ADCL1,E030024M20Rik,ELN,RATTREL11,SVAS,TREL11,Trela,Trela26,WBS,WS |
| Uniprot Accession | P15502,Q99372,P04985 |
| Uniprot Entry Name | ELN_HUMAN,ELN_RAT,ELN_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Sepsis |
| Gene Ensembl | ENSG00000049540 |
| Target Classification | N/A |
The target: ELN, gene name: ELN, also named as ADCL1, SVAS, WBS, WS. This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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