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Anti-ERLN1/ ERLIN1/ C10orf69 functional antibody
Anti-ERLN1/ ERLIN1/ C10orf69 functional antibody for cell culture, ELISA & in-vivo assay
Go to ERLIN1/ERLIN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0183-Ab-1/ GM-Tg-hg-SE0183-Ab-2 | Anti-Human ERLIN1 monoclonal antibody | Human |
| GM-Tg-rg-SE0183-Ab-1/ GM-Tg-rg-SE0183-Ab-2 | Anti-Rat ERLIN1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0183-Ab-1/ GM-Tg-mg-SE0183-Ab-2 | Anti-Mouse ERLIN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0183-Ab-1/ GM-Tg-cynog-SE0183-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ERLIN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0183-Ab-1/ GM-Tg-felg-SE0183-Ab-2 | Anti-Feline ERLIN1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0183-Ab-1/ GM-Tg-cang-SE0183-Ab-2 | Anti-Canine ERLIN1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0183-Ab-1/ GM-Tg-bovg-SE0183-Ab-2 | Anti-Bovine ERLIN1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0183-Ab-1/ GM-Tg-equg-SE0183-Ab-2 | Anti-Equine ERLIN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0183-Ab-1/ GM-Tg-hg-SE0183-Ab-2; GM-Tg-rg-SE0183-Ab-1/ GM-Tg-rg-SE0183-Ab-2; GM-Tg-mg-SE0183-Ab-1/ GM-Tg-mg-SE0183-Ab-2; GM-Tg-cynog-SE0183-Ab-1/ GM-Tg-cynog-SE0183-Ab-2; GM-Tg-felg-SE0183-Ab-1/ GM-Tg-felg-SE0183-Ab-2; GM-Tg-cang-SE0183-Ab-1/ GM-Tg-cang-SE0183-Ab-2; GM-Tg-bovg-SE0183-Ab-1/ GM-Tg-bovg-SE0183-Ab-2; GM-Tg-equg-SE0183-Ab-1/ GM-Tg-equg-SE0183-Ab-2 |
| Products Name | Anti-ERLIN1 monoclonal antibody |
| Format | mab |
| Target Name | ERLIN1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ERLIN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0183-Ag-1 | Recombinant multi-species ERLN1/ ERLIN1/ C10orf69 protein |
| ORF Viral Vector | pGMLPm004927 | mouse Erlin1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004927 | mouse Erlin1 Lentivirus particle |
Target information
| Target ID | GM-SE0183 |
| Target Name | ERLIN1 |
| Gene ID | 10613,226144,293939,709596,609141,101090647,617074,100060589 |
| Gene Symbol and Synonyms | 2810439N09Rik,C10orf69,Erlin-1,ERLIN1,KE04,KEO4,RGD1307058,SPFH1,SPG62 |
| Uniprot Accession | O75477 |
| Uniprot Entry Name | ERLN1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000107566 |
| Target Classification | N/A |
The target: ERLIN1, gene name: ERLIN1, also named as C10orf69, Erlin-1, KE04, KEO4, SPFH1, SPG62. The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. [provided by RefSeq, Dec 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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