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Anti-ERN2/ IRE1-BETA/ IRE1b functional antibody
Anti-ERN2/ IRE1-BETA/ IRE1b functional antibody for cell culture, ELISA & in-vivo assay
Go to ERN2/ERN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0184-Ab-1/ GM-Tg-hg-SE0184-Ab-2 | Anti-Human ERN2 monoclonal antibody | Human |
| GM-Tg-rg-SE0184-Ab-1/ GM-Tg-rg-SE0184-Ab-2 | Anti-Rat ERN2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0184-Ab-1/ GM-Tg-mg-SE0184-Ab-2 | Anti-Mouse ERN2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0184-Ab-1/ GM-Tg-cynog-SE0184-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ERN2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0184-Ab-1/ GM-Tg-felg-SE0184-Ab-2 | Anti-Feline ERN2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0184-Ab-1/ GM-Tg-cang-SE0184-Ab-2 | Anti-Canine ERN2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0184-Ab-1/ GM-Tg-bovg-SE0184-Ab-2 | Anti-Bovine ERN2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0184-Ab-1/ GM-Tg-equg-SE0184-Ab-2 | Anti-Equine ERN2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0184-Ab-1/ GM-Tg-hg-SE0184-Ab-2; GM-Tg-rg-SE0184-Ab-1/ GM-Tg-rg-SE0184-Ab-2; GM-Tg-mg-SE0184-Ab-1/ GM-Tg-mg-SE0184-Ab-2; GM-Tg-cynog-SE0184-Ab-1/ GM-Tg-cynog-SE0184-Ab-2; GM-Tg-felg-SE0184-Ab-1/ GM-Tg-felg-SE0184-Ab-2; GM-Tg-cang-SE0184-Ab-1/ GM-Tg-cang-SE0184-Ab-2; GM-Tg-bovg-SE0184-Ab-1/ GM-Tg-bovg-SE0184-Ab-2; GM-Tg-equg-SE0184-Ab-1/ GM-Tg-equg-SE0184-Ab-2 |
| Products Name | Anti-ERN2 monoclonal antibody |
| Format | mab |
| Target Name | ERN2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ERN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0184-Ag-1 | Recombinant multi-species ERN2/ IRE1-BETA/ IRE1b protein |
Target information
| Target ID | GM-SE0184 |
| Target Name | ERN2 |
| Gene ID | 10595,26918,365363,700910,489970,101089482,508486,100069133 |
| Gene Symbol and Synonyms | Ern1,ERN2,hIRE2p,Ire1,IRE1-BETA,IRE1b,IRE2p,mIre1 |
| Uniprot Accession | Q76MJ5 |
| Uniprot Entry Name | ERN2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000134398 |
| Target Classification | Kinase |
The target: ERN2, gene name: ERN2, also named as IRE1-BETA, IRE1b, IRE2p, hIRE2p. Enables several functions, including ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apoptotic chromosome condensation; negative regulation of transcription, DNA-templated; and rRNA catabolic process. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Predicted to be integral component of membrane. Predicted to be part of IRE1-TRAF2-ASK1 complex. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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