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Anti-FBN1/ ACMICD/ ECTOL1 functional antibody
Anti-FBN1/ ACMICD/ ECTOL1 functional antibody for cell culture, ELISA & in-vivo assay
Go to FBN1/FBN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0208-Ab-1/ GM-Tg-hg-SE0208-Ab-2 | Anti-Human FBN1 monoclonal antibody | Human |
| GM-Tg-rg-SE0208-Ab-1/ GM-Tg-rg-SE0208-Ab-2 | Anti-Rat FBN1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0208-Ab-1/ GM-Tg-mg-SE0208-Ab-2 | Anti-Mouse FBN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0208-Ab-1/ GM-Tg-cynog-SE0208-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FBN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0208-Ab-1/ GM-Tg-felg-SE0208-Ab-2 | Anti-Feline FBN1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0208-Ab-1/ GM-Tg-cang-SE0208-Ab-2 | Anti-Canine FBN1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0208-Ab-1/ GM-Tg-bovg-SE0208-Ab-2 | Anti-Bovine FBN1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0208-Ab-1/ GM-Tg-equg-SE0208-Ab-2 | Anti-Equine FBN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0208-Ab-1/ GM-Tg-hg-SE0208-Ab-2; GM-Tg-rg-SE0208-Ab-1/ GM-Tg-rg-SE0208-Ab-2; GM-Tg-mg-SE0208-Ab-1/ GM-Tg-mg-SE0208-Ab-2; GM-Tg-cynog-SE0208-Ab-1/ GM-Tg-cynog-SE0208-Ab-2; GM-Tg-felg-SE0208-Ab-1/ GM-Tg-felg-SE0208-Ab-2; GM-Tg-cang-SE0208-Ab-1/ GM-Tg-cang-SE0208-Ab-2; GM-Tg-bovg-SE0208-Ab-1/ GM-Tg-bovg-SE0208-Ab-2; GM-Tg-equg-SE0208-Ab-1/ GM-Tg-equg-SE0208-Ab-2 |
| Products Name | Anti-FBN1 monoclonal antibody |
| Format | mab |
| Target Name | FBN1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FBN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0208-Ag-1 | Recombinant multi-species FBN1/ ACMICD/ ECTOL1 protein |
Target information
| Target ID | GM-SE0208 |
| Target Name | FBN1 |
| Gene ID | 2200,14118,83727,714451,478293,101084882,281154,100055741 |
| Gene Symbol and Synonyms | ACMICD,B430209H23,ECTOL1,FBN,FBN1,Fib-1,GPHYSD2,MASS,MFLS,MFS1,OCTD,SGS,SSKS,Tsk,WMS,WMS2 |
| Uniprot Accession | P35555,P98133 |
| Uniprot Entry Name | FBN1_HUMAN,FBN1_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000166147 |
| Target Classification | N/A |
The target: FBN1, gene name: FBN1, also named as ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFLS, MFS1, OCTD, SGS, SSKS, WMS, WMS2. This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome. [provided by RefSeq, Apr 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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