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Anti-FREM1/ BNAR/ C9orf143 functional antibody
Anti-FREM1/ BNAR/ C9orf143 functional antibody for cell culture, ELISA & in-vivo assay
Go to FREM1/FREM1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0224-Ab-1/ GM-Tg-hg-SE0224-Ab-2 | Anti-Human FREM1 monoclonal antibody | Human |
| GM-Tg-rg-SE0224-Ab-1/ GM-Tg-rg-SE0224-Ab-2 | Anti-Rat FREM1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0224-Ab-1/ GM-Tg-mg-SE0224-Ab-2 | Anti-Mouse FREM1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0224-Ab-1/ GM-Tg-cynog-SE0224-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FREM1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0224-Ab-1/ GM-Tg-felg-SE0224-Ab-2 | Anti-Feline FREM1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0224-Ab-1/ GM-Tg-cang-SE0224-Ab-2 | Anti-Canine FREM1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0224-Ab-1/ GM-Tg-bovg-SE0224-Ab-2 | Anti-Bovine FREM1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0224-Ab-1/ GM-Tg-equg-SE0224-Ab-2 | Anti-Equine FREM1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0224-Ab-1/ GM-Tg-hg-SE0224-Ab-2; GM-Tg-rg-SE0224-Ab-1/ GM-Tg-rg-SE0224-Ab-2; GM-Tg-mg-SE0224-Ab-1/ GM-Tg-mg-SE0224-Ab-2; GM-Tg-cynog-SE0224-Ab-1/ GM-Tg-cynog-SE0224-Ab-2; GM-Tg-felg-SE0224-Ab-1/ GM-Tg-felg-SE0224-Ab-2; GM-Tg-cang-SE0224-Ab-1/ GM-Tg-cang-SE0224-Ab-2; GM-Tg-bovg-SE0224-Ab-1/ GM-Tg-bovg-SE0224-Ab-2; GM-Tg-equg-SE0224-Ab-1/ GM-Tg-equg-SE0224-Ab-2 |
| Products Name | Anti-FREM1 monoclonal antibody |
| Format | mab |
| Target Name | FREM1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FREM1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0224-Ag-1 | Recombinant multi-species FREM1/ BNAR/ C9orf143 protein |
Target information
| Target ID | GM-SE0224 |
| Target Name | FREM1 |
| Gene ID | 158326,329872,298185,713874,481547,102899932,508018,100062297 |
| Gene Symbol and Synonyms | BNAR,C9orf143,C9orf145,C9orf154,crf11,D430009N09,D630008K06,eye |
| Uniprot Accession | Q5H8C1 |
| Uniprot Entry Name | FREM1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000164946 |
| Target Classification | N/A |
The target: FREM1, gene name: FREM1, also named as BNAR, C9orf143, C9orf145, C9orf154, MOTA, TILRR, TRIGNO2. This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation. [provided by RefSeq, Apr 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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