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Anti-GNS/ G6S functional antibody
Anti-GNS/ G6S functional antibody for cell culture, ELISA & in-vivo assay
Go to GNS/GNS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0247-Ab-1/ GM-Tg-hg-SE0247-Ab-2 | Anti-Human GNS monoclonal antibody | Human |
| GM-Tg-rg-SE0247-Ab-1/ GM-Tg-rg-SE0247-Ab-2 | Anti-Rat GNS monoclonal antibody | Rat |
| GM-Tg-mg-SE0247-Ab-1/ GM-Tg-mg-SE0247-Ab-2 | Anti-Mouse GNS monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0247-Ab-1/ GM-Tg-cynog-SE0247-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GNS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0247-Ab-1/ GM-Tg-felg-SE0247-Ab-2 | Anti-Feline GNS monoclonal antibody | Feline |
| GM-Tg-cang-SE0247-Ab-1/ GM-Tg-cang-SE0247-Ab-2 | Anti-Canine GNS monoclonal antibody | Canine |
| GM-Tg-bovg-SE0247-Ab-1/ GM-Tg-bovg-SE0247-Ab-2 | Anti-Bovine GNS monoclonal antibody | Bovine |
| GM-Tg-equg-SE0247-Ab-1/ GM-Tg-equg-SE0247-Ab-2 | Anti-Equine GNS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0247-Ab-1/ GM-Tg-hg-SE0247-Ab-2; GM-Tg-rg-SE0247-Ab-1/ GM-Tg-rg-SE0247-Ab-2; GM-Tg-mg-SE0247-Ab-1/ GM-Tg-mg-SE0247-Ab-2; GM-Tg-cynog-SE0247-Ab-1/ GM-Tg-cynog-SE0247-Ab-2; GM-Tg-felg-SE0247-Ab-1/ GM-Tg-felg-SE0247-Ab-2; GM-Tg-cang-SE0247-Ab-1/ GM-Tg-cang-SE0247-Ab-2; GM-Tg-bovg-SE0247-Ab-1/ GM-Tg-bovg-SE0247-Ab-2; GM-Tg-equg-SE0247-Ab-1/ GM-Tg-equg-SE0247-Ab-2 |
| Products Name | Anti-GNS monoclonal antibody |
| Format | mab |
| Target Name | GNS |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GNS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0247-Ag-1 | Recombinant multi-species GNS/ G6S protein |
| ORF Viral Vector | pGMLPm002748 | mouse Gns Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002748 | mouse Gns Lentivirus particle |
Target information
| Target ID | GM-SE0247 |
| Target Name | GNS |
| Gene ID | 2799,75612,299825,717500,474429,101088174,512444,100034131 |
| Gene Symbol and Synonyms | 2610016K11Rik,G6S,GNS |
| Uniprot Accession | P15586,Q1LZH9 |
| Uniprot Entry Name | GNS_HUMAN,GNS_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000135677 |
| Target Classification | N/A |
The target: GNS, gene name: GNS, also named as G6S. The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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