Anti-GXLT1/ GXYLT1/ GLT8D3 functional antibody

Anti-GXLT1/ GXYLT1/ GLT8D3 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to GXYLT1/GXYLT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0251-Ab-1/ GM-Tg-hg-SE0251-Ab-2Anti-Human GXYLT1 monoclonal antibodyHuman
GM-Tg-rg-SE0251-Ab-1/ GM-Tg-rg-SE0251-Ab-2Anti-Rat GXYLT1 monoclonal antibodyRat
GM-Tg-mg-SE0251-Ab-1/ GM-Tg-mg-SE0251-Ab-2Anti-Mouse GXYLT1 monoclonal antibodyMouse
GM-Tg-cynog-SE0251-Ab-1/ GM-Tg-cynog-SE0251-Ab-2Anti-Cynomolgus/ Rhesus macaque GXYLT1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0251-Ab-1/ GM-Tg-felg-SE0251-Ab-2Anti-Feline GXYLT1 monoclonal antibodyFeline
GM-Tg-cang-SE0251-Ab-1/ GM-Tg-cang-SE0251-Ab-2Anti-Canine GXYLT1 monoclonal antibodyCanine
GM-Tg-bovg-SE0251-Ab-1/ GM-Tg-bovg-SE0251-Ab-2Anti-Bovine GXYLT1 monoclonal antibodyBovine
GM-Tg-equg-SE0251-Ab-1/ GM-Tg-equg-SE0251-Ab-2Anti-Equine GXYLT1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0251-Ab-1/ GM-Tg-hg-SE0251-Ab-2; GM-Tg-rg-SE0251-Ab-1/ GM-Tg-rg-SE0251-Ab-2;
GM-Tg-mg-SE0251-Ab-1/ GM-Tg-mg-SE0251-Ab-2; GM-Tg-cynog-SE0251-Ab-1/ GM-Tg-cynog-SE0251-Ab-2;
GM-Tg-felg-SE0251-Ab-1/ GM-Tg-felg-SE0251-Ab-2; GM-Tg-cang-SE0251-Ab-1/ GM-Tg-cang-SE0251-Ab-2;
GM-Tg-bovg-SE0251-Ab-1/ GM-Tg-bovg-SE0251-Ab-2; GM-Tg-equg-SE0251-Ab-1/ GM-Tg-equg-SE0251-Ab-2
Products NameAnti-GXYLT1 monoclonal antibody
Formatmab
Target NameGXYLT1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GXYLT1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0251-Ag-1Recombinant multi-species GXLT1/ GXYLT1/ GLT8D3 protein


    Target information

    Target IDGM-SE0251
    Target NameGXYLT1
    Gene ID283464,223827,300173,698940,486604,101099221,617596,100054009
    Gene Symbol and SynonymsGLT8D3,Gm1228,Gm87,GXYLT1
    Uniprot AccessionQ4G148,Q6GX83
    Uniprot Entry NameGXLT1_HUMAN,GXLT1_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000151233
    Target ClassificationN/A

    The target: GXYLT1, gene name: GXYLT1, also named as GLT8D3. GXYLT1 is a xylosyltransferase (EC 2.4.2.-) that adds the first xylose to O-glucose-modified residues in the epidermal growth factor (EGF; MIM 131530) repeats of proteins such as NOTCH1 (MIM 190198) (Sethi et al., 2010 [PubMed 19940119]).[supplied by OMIM, Mar 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.