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Anti-HEXA/ TSD functional antibody
Anti-HEXA/ TSD functional antibody for cell culture, ELISA & in-vivo assay
Go to HEXA/HEXA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0259-Ab-1/ GM-Tg-hg-SE0259-Ab-2 | Anti-Human HEXA monoclonal antibody | Human |
| GM-Tg-rg-SE0259-Ab-1/ GM-Tg-rg-SE0259-Ab-2 | Anti-Rat HEXA monoclonal antibody | Rat |
| GM-Tg-mg-SE0259-Ab-1/ GM-Tg-mg-SE0259-Ab-2 | Anti-Mouse HEXA monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0259-Ab-1/ GM-Tg-cynog-SE0259-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HEXA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0259-Ab-1/ GM-Tg-felg-SE0259-Ab-2 | Anti-Feline HEXA monoclonal antibody | Feline |
| GM-Tg-cang-SE0259-Ab-1/ GM-Tg-cang-SE0259-Ab-2 | Anti-Canine HEXA monoclonal antibody | Canine |
| GM-Tg-bovg-SE0259-Ab-1/ GM-Tg-bovg-SE0259-Ab-2 | Anti-Bovine HEXA monoclonal antibody | Bovine |
| GM-Tg-equg-SE0259-Ab-1/ GM-Tg-equg-SE0259-Ab-2 | Anti-Equine HEXA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0259-Ab-1/ GM-Tg-hg-SE0259-Ab-2; GM-Tg-rg-SE0259-Ab-1/ GM-Tg-rg-SE0259-Ab-2; GM-Tg-mg-SE0259-Ab-1/ GM-Tg-mg-SE0259-Ab-2; GM-Tg-cynog-SE0259-Ab-1/ GM-Tg-cynog-SE0259-Ab-2; GM-Tg-felg-SE0259-Ab-1/ GM-Tg-felg-SE0259-Ab-2; GM-Tg-cang-SE0259-Ab-1/ GM-Tg-cang-SE0259-Ab-2; GM-Tg-bovg-SE0259-Ab-1/ GM-Tg-bovg-SE0259-Ab-2; GM-Tg-equg-SE0259-Ab-1/ GM-Tg-equg-SE0259-Ab-2 |
| Products Name | Anti-HEXA monoclonal antibody |
| Format | mab |
| Target Name | HEXA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HEXA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0259-Ag-1 | Recombinant multi-species HEXA/ TSD protein |
| ORF Viral Vector | vGMLP001148 | human HEXA Lentivirus particle |
| ORF Viral Vector | pGMLP001148 | human HEXA Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005035 | mouse Hexa Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005035 | mouse Hexa Lentivirus particle |
Target information
| Target ID | GM-SE0259 |
| Target Name | HEXA |
| Gene ID | 3073,15211,300757,698251,487633,101091627,504468,100063584 |
| Gene Symbol and Synonyms | Hex-1,HEXA,TSD |
| Uniprot Accession | P06865,Q641X3,Q0V8R6 |
| Uniprot Entry Name | HEXA_HUMAN,HEXA_RAT,HEXA_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000213614 |
| Target Classification | N/A |
The target: HEXA, gene name: HEXA, also named as TSD. This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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