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Anti-HEXB/ ENC-1AS/ HEL-248 functional antibody
Anti-HEXB/ ENC-1AS/ HEL-248 functional antibody for cell culture, ELISA & in-vivo assay
Go to HEXB/HEXB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0260-Ab-1/ GM-Tg-hg-SE0260-Ab-2 | Anti-Human HEXB monoclonal antibody | Human |
| GM-Tg-rg-SE0260-Ab-1/ GM-Tg-rg-SE0260-Ab-2 | Anti-Rat HEXB monoclonal antibody | Rat |
| GM-Tg-mg-SE0260-Ab-1/ GM-Tg-mg-SE0260-Ab-2 | Anti-Mouse HEXB monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0260-Ab-1/ GM-Tg-cynog-SE0260-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HEXB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0260-Ab-1/ GM-Tg-felg-SE0260-Ab-2 | Anti-Feline HEXB monoclonal antibody | Feline |
| GM-Tg-cang-SE0260-Ab-1/ GM-Tg-cang-SE0260-Ab-2 | Anti-Canine HEXB monoclonal antibody | Canine |
| GM-Tg-bovg-SE0260-Ab-1/ GM-Tg-bovg-SE0260-Ab-2 | Anti-Bovine HEXB monoclonal antibody | Bovine |
| GM-Tg-equg-SE0260-Ab-1/ GM-Tg-equg-SE0260-Ab-2 | Anti-Equine HEXB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0260-Ab-1/ GM-Tg-hg-SE0260-Ab-2; GM-Tg-rg-SE0260-Ab-1/ GM-Tg-rg-SE0260-Ab-2; GM-Tg-mg-SE0260-Ab-1/ GM-Tg-mg-SE0260-Ab-2; GM-Tg-cynog-SE0260-Ab-1/ GM-Tg-cynog-SE0260-Ab-2; GM-Tg-felg-SE0260-Ab-1/ GM-Tg-felg-SE0260-Ab-2; GM-Tg-cang-SE0260-Ab-1/ GM-Tg-cang-SE0260-Ab-2; GM-Tg-bovg-SE0260-Ab-1/ GM-Tg-bovg-SE0260-Ab-2; GM-Tg-equg-SE0260-Ab-1/ GM-Tg-equg-SE0260-Ab-2 |
| Products Name | Anti-HEXB monoclonal antibody |
| Format | mab |
| Target Name | HEXB |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HEXB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0260-Ag-1 | Recombinant multi-species HEXB/ ENC-1AS/ HEL-248 protein |
| ORF Viral Vector | vGMLP002113 | human HEXB Lentivirus particle |
| ORF Viral Vector | pGMLP002113 | human HEXB Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005361 | mouse Hexb Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005361 | mouse Hexb Lentivirus particle |
Target information
| Target ID | GM-SE0260 |
| Target Name | HEXB |
| Gene ID | 3074,15212,294673,704464,478100,493928,618571,100073289 |
| Gene Symbol and Synonyms | ENC-1AS,HEL-248,HEL-S-111,HEXB |
| Uniprot Accession | P07686,Q6AXR4,P49614 |
| Uniprot Entry Name | HEXB_HUMAN,HEXB_RAT,HEXB_FELCA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000049860 |
| Target Classification | N/A |
The target: HEXB, gene name: HEXB, also named as ENC-1AS, HEL-248, HEL-S-111. Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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